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<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>1025 - Disclosure - BALANCE SHEET COMPONENTS (Tables)</link:definition>
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<link:definition>1026 - Disclosure - STOCKHOLDERS' EQUITY (Tables)</link:definition>
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<link:definition>1027 - Disclosure - STOCK BASED COMPENSATION (Tables)</link:definition>
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<link:definition>1028 - Disclosure - INCOME TAXES (Tables)</link:definition>
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<link:definition>1029 - Disclosure - COMMITMENTS AND CONTINGENCIES (Tables)</link:definition>
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<link:definition>1030 - Disclosure - QUARTERLY UNAUDITED RESULTS (Tables)</link:definition>
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<link:definition>1031 - Disclosure - GENERAL ORGANIZATION, BUSINESS AND LIQUIDITY (Details Textual)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>1032 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES (Details)</link:definition>
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<link:definition>1038 - Disclosure - CASH AND CASH EQUIVALENTS, AND SHORT-TERM INVESTMENTS (Details 1)</link:definition>
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<link:definition>1039 - Disclosure - CASH AND CASH EQUIVALENTS, AND SHORT-TERM INVESTMENTS (Details 2)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>1040 - Disclosure - BALANCE SHEET COMPONENTS (Details)</link:definition>
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<link:definition>1041 - Disclosure - BALANCE SHEET COMPONENTS (Details 1)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>1042 - Disclosure - BALANCE SHEET COMPONENTS (Details Textual)</link:definition>
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<link:definition>1045 - Disclosure - STOCK BASED COMPENSATION (Details)</link:definition>
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<link:definition>1046 - Disclosure - STOCK BASED COMPENSATION (Details 1)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>1048 - Disclosure - STOCK BASED COMPENSATION (Details 3)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>1049 - Disclosure - STOCK BASED COMPENSATION (Details Textual)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>1050 - Disclosure - EMPLOYEE BENEFIT PLAN (Details Textual)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1051 - Disclosure - SEPARATION AGREEMENTS (Details Textual)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:definition>1052 - Disclosure - INCOME TAXES (Details)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:roleType roleURI="http://lbio.com/role/IncomeTaxesDetails1" id="IncomeTaxesDetails1">
<link:definition>1053 - Disclosure - INCOME TAXES (Details 1)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:roleType roleURI="http://lbio.com/role/IncomeTaxesDetails2" id="IncomeTaxesDetails2">
<link:definition>1054 - Disclosure - INCOME TAXES (Details 2)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>1055 - Disclosure - INCOME TAXES (Details 3)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
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<link:roleType roleURI="http://lbio.com/role/IncomeTaxesDetailsTextual" id="IncomeTaxesDetailsTextual">
<link:definition>1056 - Disclosure - INCOME TAXES (Details Textual)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
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<link:definition>1057 - Disclosure - LICENSES AND AGREEMENTS (Details Textual)</link:definition>
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<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:roleType roleURI="http://lbio.com/role/CommitmentsAndContingenciesDetails" id="CommitmentsAndContingenciesDetails">
<link:definition>1058 - Disclosure - COMMITMENTS AND CONTINGENCIES (Details)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
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<link:roleType roleURI="http://lbio.com/role/CommitmentsAndContingenciesDetailsTextual" id="CommitmentsAndContingenciesDetailsTextual">
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<element name="OfficeSpaceMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_OfficeSpaceMember" substitutionGroup="xbrli:item" />
<element name="SolomonCapitalLlcMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_SolomonCapitalLlcMember" substitutionGroup="xbrli:item" />
<element name="StevenFischkoffMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_StevenFischkoffMember" substitutionGroup="xbrli:item" />
<element name="CommonStockRegisteredForResale" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="iova_CommonStockRegisteredForResale" substitutionGroup="xbrli:item" />
<element name="SharesSoldUnderIneffectiveRegistration" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="iova_SharesSoldUnderIneffectiveRegistration" substitutionGroup="xbrli:item" />
<element name="NumberOfShareOptionsOrShareUnitsExercisedDuringCurrentPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="iova_NumberOfShareOptionsOrShareUnitsExercisedDuringCurrentPeriod" substitutionGroup="xbrli:item" />
<element name="SeverancePayAndRetentionBonus" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="iova_SeverancePayAndRetentionBonus" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="TwentyElevenEquityIncentivePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_TwentyElevenEquityIncentivePlanMember" substitutionGroup="xbrli:item" />
<element name="PaymentsForLegalServices" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="iova_PaymentsForLegalServices" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ConsultingAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_ConsultingAgreementMember" substitutionGroup="xbrli:item" />
</schema>
