<?xml version="1.0" encoding="us-ascii"?>
<!--XBRL document created with Toppan Merrill Bridge  9.5.7293.39921 -->
<!--Based on XBRL 2.1-->
<!--Created on: 2/25/2020 8:33:55 PM-->
<!--Modified on: 2/25/2020 8:33:55 PM-->
<schema xmlns:exch="http://xbrl.sec.gov/exch/2019-01-31" xmlns:us-types="http://fasb.org/us-types/2019-01-31" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:srt="http://fasb.org/srt/2019-01-31" xmlns:stpr="http://xbrl.sec.gov/stpr/2018-01-31" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:iova="http://lbio.com/20191231" xmlns:xl="http://www.xbrl.org/2003/XLink" xmlns:country="http://xbrl.sec.gov/country/2017-01-31" xmlns:naics="http://xbrl.sec.gov/naics/2017-01-31" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:deprecated="http://www.xbrl.org/2009/arcrole/fact-explanatoryFact" xmlns:sic="http://xbrl.sec.gov/sic/2011-01-31" xmlns:us-gaap="http://fasb.org/us-gaap/2019-01-31" xmlns:invest="http://xbrl.sec.gov/invest/2013-01-31" xmlns:currency="http://xbrl.sec.gov/currency/2019-01-31" xmlns:dei="http://xbrl.sec.gov/dei/2019-01-31" xmlns="http://www.w3.org/2001/XMLSchema" targetNamespace="http://lbio.com/20191231" elementFormDefault="qualified">
  <annotation>
    <appinfo>
      <link:roleType roleURI="http://lbio.com/role/StatementCondensedConsolidatedBalanceSheets" id="StatementCondensedConsolidatedBalanceSheets">
        <link:definition>00100 - Statement - Condensed Consolidated Balance Sheets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/StatementCondensedConsolidatedStatementsOfOperations" id="StatementCondensedConsolidatedStatementsOfOperations">
        <link:definition>00200 - Statement - Condensed Consolidated Statements of Operations</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/StatementCondensedConsolidatedStatementsOfComprehensiveLoss" id="StatementCondensedConsolidatedStatementsOfComprehensiveLoss">
        <link:definition>00300 - Statement - Condensed Consolidated Statements of Comprehensive Loss</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/StatementCondensedConsolidatedStatementsOfCashFlows" id="StatementCondensedConsolidatedStatementsOfCashFlows">
        <link:definition>00500 - Statement - Condensed Consolidated Statements of Cash Flows</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPracticesCashCashEquivalentsAndRestrictedCashDetails" id="DisclosureSummaryOfSignificantAccountingPracticesCashCashEquivalentsAndRestrictedCashDetails">
        <link:definition>40201 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES - Cash, Cash equivalents and Restricted Cash (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureBalanceSheetComponentsAccruedLiabilitiesDetails" id="DisclosureBalanceSheetComponentsAccruedLiabilitiesDetails">
        <link:definition>40401 - Disclosure - BALANCE SHEET COMPONENTS - Accrued liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureBalanceSheetComponentsAdditionalInformationDetails" id="DisclosureBalanceSheetComponentsAdditionalInformationDetails">
        <link:definition>40403 - Disclosure - BALANCE SHEET COMPONENTS - Additional information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIncomeTaxesDetails" id="DisclosureIncomeTaxesDetails">
        <link:definition>40801 - Disclosure - INCOME TAXES (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIncomeTaxesRateReconciliationDetails" id="DisclosureIncomeTaxesRateReconciliationDetails">
        <link:definition>40802 - Disclosure - INCOME TAXES - Rate reconciliation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIncomeTaxesExpenseComponentsDetails" id="DisclosureIncomeTaxesExpenseComponentsDetails">
        <link:definition>40803 - Disclosure - INCOME TAXES - Expense components (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLeasesCompanySRightOfUseAssetAndLeaseLiabilitiesDetails" id="DisclosureLeasesCompanySRightOfUseAssetAndLeaseLiabilitiesDetails">
        <link:definition>41001 - Disclosure - LEASES - Company's right-of-use asset and lease liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLeasesComponentsOfLeaseExpensesDetails" id="DisclosureLeasesComponentsOfLeaseExpensesDetails">
        <link:definition>41002 - Disclosure - LEASES - components of lease expenses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLeasesMaturitiesOfCompanySOperatingLeaseLiabilitiesDetails" id="DisclosureLeasesMaturitiesOfCompanySOperatingLeaseLiabilitiesDetails">
        <link:definition>41003 - Disclosure - LEASES - maturities of the Company's operating lease liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLeasesMaturitiesOfCompanySOperatingLeaseLiabilitiesDetailsCalc2" id="DisclosureLeasesMaturitiesOfCompanySOperatingLeaseLiabilitiesDetailsCalc2">
        <link:definition>41003 - Disclosure - LEASES - maturities of the Company's operating lease liabilities (Details) Calc 2</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DocumentDocumentAndEntityInformation" id="DocumentDocumentAndEntityInformation">
        <link:definition>00090 - Document - Document And Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/StatementCondensedConsolidatedBalanceSheetsParenthetical" id="StatementCondensedConsolidatedBalanceSheetsParenthetical">
        <link:definition>00105 - Statement - Condensed Consolidated Balance Sheets (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/StatementCondensedConsolidatedStatementsOfStockholdersEquity" id="StatementCondensedConsolidatedStatementsOfStockholdersEquity">
        <link:definition>00400 - Statement - Condensed Consolidated Statements of Stockholders' Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureGeneralOrganizationAndBusinessDetails" id="DisclosureGeneralOrganizationAndBusinessDetails">
        <link:definition>40101 - Disclosure - GENERAL ORGANIZATION AND BUSINESS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPracticesUsefulLivesImpairmentDetails" id="DisclosureSummaryOfSignificantAccountingPracticesUsefulLivesImpairmentDetails">
        <link:definition>40202 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES - Useful lives, impairment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPracticesLossPerShareDetails" id="DisclosureSummaryOfSignificantAccountingPracticesLossPerShareDetails">
        <link:definition>40203 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES - Loss per share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPracticesFairValueDetails" id="DisclosureSummaryOfSignificantAccountingPracticesFairValueDetails">
        <link:definition>40204 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES - Fair value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPracticesStockBasedCompensationExpenseDetails" id="DisclosureSummaryOfSignificantAccountingPracticesStockBasedCompensationExpenseDetails">
        <link:definition>40205 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES - Stock-based compensation expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPracticesStockBasedCompensationByInstrumentDetails" id="DisclosureSummaryOfSignificantAccountingPracticesStockBasedCompensationByInstrumentDetails">
        <link:definition>40206 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES - Stock-based compensation by instrument (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPracticesConcentrationsEtcDetails" id="DisclosureSummaryOfSignificantAccountingPracticesConcentrationsEtcDetails">
        <link:definition>40207 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES - Concentrations, etc. (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPracticesAdditionalInformationDetails" id="DisclosureSummaryOfSignificantAccountingPracticesAdditionalInformationDetails">
        <link:definition>40208 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES - Additional information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureCashAndCashEquivalentsAndShortTermInvestmentsDetails" id="DisclosureCashAndCashEquivalentsAndShortTermInvestmentsDetails">
        <link:definition>40301 - Disclosure - CASH AND CASH EQUIVALENTS, AND SHORT-TERM INVESTMENTS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureCashAndCashEquivalentsAndShortTermInvestmentsShortTermInvestmentsDetails" id="DisclosureCashAndCashEquivalentsAndShortTermInvestmentsShortTermInvestmentsDetails">
        <link:definition>40302 - Disclosure - CASH AND CASH EQUIVALENTS, AND SHORT-TERM INVESTMENTS - Short-term investments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureCashAndCashEquivalentsAndShortTermInvestmentsCostAndFairValueDetails" id="DisclosureCashAndCashEquivalentsAndShortTermInvestmentsCostAndFairValueDetails">
        <link:definition>40303 - Disclosure - CASH AND CASH EQUIVALENTS, AND SHORT-TERM INVESTMENTS - Cost and fair value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureBalanceSheetComponentsOtherInformationDetails" id="DisclosureBalanceSheetComponentsOtherInformationDetails">
        <link:definition>40402 - Disclosure - BALANCE SHEET COMPONENTS - Other information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockholdersEquityWarrantActivityDetails" id="DisclosureStockholdersEquityWarrantActivityDetails">
        <link:definition>40501 - Disclosure - STOCKHOLDERS' EQUITY - Warrant activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockholdersEquityAdditionalInformationDetails" id="DisclosureStockholdersEquityAdditionalInformationDetails">
        <link:definition>40502 - Disclosure - STOCKHOLDERS' EQUITY - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockBasedCompensationStockOptionsDetails" id="DisclosureStockBasedCompensationStockOptionsDetails">
        <link:definition>40601 - Disclosure - STOCK BASED COMPENSATION - Stock Options (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockBasedCompensationAssumptionsDetails" id="DisclosureStockBasedCompensationAssumptionsDetails">
        <link:definition>40602 - Disclosure - STOCK BASED COMPENSATION - Assumptions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockBasedCompensationExercisePriceDetails" id="DisclosureStockBasedCompensationExercisePriceDetails">
        <link:definition>40603 - Disclosure - STOCK BASED COMPENSATION - Exercise price (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockBasedCompensationAdditionalInformationDetails" id="DisclosureStockBasedCompensationAdditionalInformationDetails">
        <link:definition>40604 - Disclosure - STOCK BASED COMPENSATION - Additional information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureEmployeeBenefitPlanDetails" id="DisclosureEmployeeBenefitPlanDetails">
        <link:definition>40701 - Disclosure - EMPLOYEE BENEFIT PLAN (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIncomeTaxesUnrecognizedBenefitsDetails" id="DisclosureIncomeTaxesUnrecognizedBenefitsDetails">
        <link:definition>40804 - Disclosure - INCOME TAXES - Unrecognized benefits (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIncomeTaxesOtherInformationDetails" id="DisclosureIncomeTaxesOtherInformationDetails">
        <link:definition>40805 - Disclosure - INCOME TAXES - Other information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLicensesAndAgreementsDetails" id="DisclosureLicensesAndAgreementsDetails">
        <link:definition>40901 - Disclosure - LICENSES AND AGREEMENTS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLeasesAdditionalInformationDetails" id="DisclosureLeasesAdditionalInformationDetails">
        <link:definition>41004 - Disclosure - LEASES - Additional information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLegalProceedingsDetails" id="DisclosureLegalProceedingsDetails">
        <link:definition>41101 - Disclosure - LEGAL PROCEEDINGS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureQuarterlyUnauditedResultsDetails" id="DisclosureQuarterlyUnauditedResultsDetails">
        <link:definition>41201 - Disclosure - QUARTERLY UNAUDITED RESULTS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureRelatedPartyTransactionsDetails" id="DisclosureRelatedPartyTransactionsDetails">
        <link:definition>41301 - Disclosure - RELATED PARTY TRANSACTIONS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureGeneralOrganizationAndBusiness" id="DisclosureGeneralOrganizationAndBusiness">
        <link:definition>10101 - Disclosure - GENERAL ORGANIZATION AND BUSINESS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPractices" id="DisclosureSummaryOfSignificantAccountingPractices">
        <link:definition>10201 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureCashAndCashEquivalentsAndShortTermInvestments" id="DisclosureCashAndCashEquivalentsAndShortTermInvestments">
        <link:definition>10301 - Disclosure - CASH AND CASH EQUIVALENTS, AND SHORT-TERM INVESTMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureBalanceSheetComponents" id="DisclosureBalanceSheetComponents">
        <link:definition>10401 - Disclosure - BALANCE SHEET COMPONENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockholdersEquity" id="DisclosureStockholdersEquity">
        <link:definition>10501 - Disclosure - STOCKHOLDERS' EQUITY</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockBasedCompensation" id="DisclosureStockBasedCompensation">
        <link:definition>10601 - Disclosure - STOCK BASED COMPENSATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureEmployeeBenefitPlan" id="DisclosureEmployeeBenefitPlan">
        <link:definition>10701 - Disclosure - EMPLOYEE BENEFIT PLAN</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIncomeTaxes" id="DisclosureIncomeTaxes">
        <link:definition>10801 - Disclosure - INCOME TAXES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLicensesAndAgreements" id="DisclosureLicensesAndAgreements">
        <link:definition>10901 - Disclosure - LICENSES AND AGREEMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLeases" id="DisclosureLeases">
        <link:definition>11001 - Disclosure - LEASES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLegalProceedings" id="DisclosureLegalProceedings">
        <link:definition>11101 - Disclosure - LEGAL PROCEEDINGS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureQuarterlyUnauditedResults" id="DisclosureQuarterlyUnauditedResults">
        <link:definition>11201 - Disclosure - QUARTERLY UNAUDITED RESULTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureRelatedPartyTransactions" id="DisclosureRelatedPartyTransactions">
        <link:definition>11301 - Disclosure - RELATED PARTY TRANSACTIONS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPracticesPolicies" id="DisclosureSummaryOfSignificantAccountingPracticesPolicies">
        <link:definition>20202 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPracticesTables" id="DisclosureSummaryOfSignificantAccountingPracticesTables">
        <link:definition>30203 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureCashAndCashEquivalentsAndShortTermInvestmentsTables" id="DisclosureCashAndCashEquivalentsAndShortTermInvestmentsTables">
        <link:definition>30303 - Disclosure - CASH AND CASH EQUIVALENTS, AND SHORT-TERM INVESTMENTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureBalanceSheetComponentsTables" id="DisclosureBalanceSheetComponentsTables">
        <link:definition>30403 - Disclosure - BALANCE SHEET COMPONENTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockholdersEquityTables" id="DisclosureStockholdersEquityTables">
        <link:definition>30503 - Disclosure - STOCKHOLDERS' EQUITY (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockBasedCompensationTables" id="DisclosureStockBasedCompensationTables">
        <link:definition>30603 - Disclosure - STOCK BASED COMPENSATION (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIncomeTaxesTables" id="DisclosureIncomeTaxesTables">
        <link:definition>30903 - Disclosure - INCOME TAXES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLeasesTables" id="DisclosureLeasesTables">
        <link:definition>31003 - Disclosure - LEASES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureQuarterlyUnauditedResultsTables" id="DisclosureQuarterlyUnauditedResultsTables">
        <link:definition>31203 - Disclosure - QUARTERLY UNAUDITED RESULTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:linkbaseRef xlink:type="simple" xlink:href="iova-20191231_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="iova-20191231_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="iova-20191231_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="iova-20191231_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
    </appinfo>
  </annotation>
  <import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" />
  <import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
  <import namespace="http://www.xbrl.org/2009/role/net" schemaLocation="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd" />
  <import namespace="http://xbrl.sec.gov/dei/2019-01-31" schemaLocation="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd" />
  <import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" />
  <import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" />
  <import namespace="http://fasb.org/us-roles/2019-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2019/elts/us-roles-2019-01-31.xsd" />
  <import namespace="http://fasb.org/us-gaap/2019-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2019/elts/us-gaap-2019-01-31.xsd" />
  <import namespace="http://fasb.org/srt/2019-01-31" schemaLocation="http://xbrl.fasb.org/srt/2019/elts/srt-2019-01-31.xsd" />
  <element name="DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_DocumentAndEntityInformationAbstract" substitutionGroup="xbrli:item" />
  <element name="CommonStockIssuedUponExerciseOfWarrantsAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="iova_CommonStockIssuedUponExerciseOfWarrantsAmount" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <element name="CommonStockIssuedUponExerciseOfWarrantsShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="iova_CommonStockIssuedUponExerciseOfWarrantsShares" substitutionGroup="xbrli:item" />
  <element id="iova_StockCancelledDuringPeriodRestrictedShares" name="StockCancelledDuringPeriodRestrictedShares" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_UnrealizedGainLossOnShorttermInvestments" name="UnrealizedGainLossOnShorttermInvestments" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element name="LeaseholdImprovementsPaidByLandlord" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="iova_LeaseholdImprovementsPaidByLandlord" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <element name="LicensesAndAgreementsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_LicensesAndAgreementsAbstract" substitutionGroup="xbrli:item" />
  <element name="LicensesAndAgreementsDisclosureTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="iova_LicensesAndAgreementsDisclosureTextBlock" substitutionGroup="xbrli:item" />
  <element name="ConvertibleInstrumentsPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="iova_ConvertibleInstrumentsPolicyTextBlock" substitutionGroup="xbrli:item" />
  <element id="iova_AvailableForSaleSecuritiesAccumulatedAccretion" name="AvailableForSaleSecuritiesAccumulatedAccretion" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <element name="LegalAndRelatedServicesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="iova_LegalAndRelatedServicesCurrent" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <element name="ClinicalRelatedExpensesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="iova_ClinicalRelatedExpensesCurrent" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <element name="ManufacturingRelatedExpensesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="iova_ManufacturingRelatedExpensesCurrent" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <element name="SharebasedcompensationarrangementbysharebasedpaymentawardoptionsadditionaldisclosuresAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_SharebasedcompensationarrangementbysharebasedpaymentawardoptionsadditionaldisclosuresAbstract" substitutionGroup="xbrli:item" />
  <element name="SeriesConvertiblePreferredStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_SeriesConvertiblePreferredStockMember" substitutionGroup="xbrli:item" />
  <element name="IssuanceOfCommonStockUponConversionOfPreferredStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_IssuanceOfCommonStockUponConversionOfPreferredStockMember" substitutionGroup="xbrli:item" />
  <element id="iova_ConvertiblePricePerShares" name="ConvertiblePricePerShares" nillable="true" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_ProceedsFromIssuanceOfCommonStockGross" name="ProceedsFromIssuanceOfCommonStockGross" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="iova_RangeOfExercisePricesOneMember" name="RangeOfExercisePricesOneMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_RangeOfExercisePricesTwoMember" name="RangeOfExercisePricesTwoMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_RangeOfExercisePricesThreeMember" name="RangeOfExercisePricesThreeMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_RangeOfExercisePricesFourMember" name="RangeOfExercisePricesFourMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_RangeOfExercisePricesFiveMember" name="RangeOfExercisePricesFiveMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_RangeOfExercisePricesSixMember" name="RangeOfExercisePricesSixMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_RangeOfExercisePricesSevenMember" name="RangeOfExercisePricesSevenMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_RangeOfExercisePricesEightMember" name="RangeOfExercisePricesEightMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_RangeOfExercisePricesNineMember" name="RangeOfExercisePricesNineMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_RangeOfExercisePricesTenMember" name="RangeOfExercisePricesTenMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element name="TwoThousandElevenEquityIncentivePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_TwoThousandElevenEquityIncentivePlanMember" substitutionGroup="xbrli:item" />
  <element name="EquityIncentivePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_EquityIncentivePlanMember" substitutionGroup="xbrli:item" />
  <element id="iova_TwentyEighteenEquityIncentivePlanMember" name="TwentyEighteenEquityIncentivePlanMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element name="DeferredTaxLiabilitiesDepreciationAndAmortization" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="iova_DeferredTaxLiabilitiesDepreciationAndAmortization" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <element name="OperatingLossCarryForwardsHavingDefiniteExpireLifeValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="iova_OperatingLossCarryForwardsHavingDefiniteExpireLifeValue" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <element name="OperatingLossCarryForwardsHavingIndefiniteExpireLifeValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="iova_OperatingLossCarryForwardsHavingIndefiniteExpireLifeValue" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <element name="CooperativeResearchAndDevelopmentAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_CooperativeResearchAndDevelopmentAgreementMember" substitutionGroup="xbrli:item" />
  <element name="WuxiApptechIncManufacturingAndServicesAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_WuxiApptechIncManufacturingAndServicesAgreementMember" substitutionGroup="xbrli:item" />
  <element name="MoffittLicenseAgreementTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_MoffittLicenseAgreementTwoMember" substitutionGroup="xbrli:item" />
  <element name="MoffittLicenseAgreementOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_MoffittLicenseAgreementOneMember" substitutionGroup="xbrli:item" />
  <element name="ManufacturingSuitesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_ManufacturingSuitesMember" substitutionGroup="xbrli:item" />
  <element name="StrategicAllianceAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_StrategicAllianceAgreementMember" substitutionGroup="xbrli:item" />
  <element name="ResearchCollaborationAndClinicalGrantAgreementsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_ResearchCollaborationAndClinicalGrantAgreementsMember" substitutionGroup="xbrli:item" />
  <element id="iova_PaymentsForUpfrontLicensingFee" name="PaymentsForUpfrontLicensingFee" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="iova_AgreementTerm" name="AgreementTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element name="FacilityLeasesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_FacilityLeasesMember" substitutionGroup="xbrli:item" />
  <element name="TampaLeaseMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_TampaLeaseMember" substitutionGroup="xbrli:item" />
  <element name="NewYorkLeaseMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_NewYorkLeaseMember" substitutionGroup="xbrli:item" />
  <element name="SanCarlosLeaseMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_SanCarlosLeaseMember" substitutionGroup="xbrli:item" />
  <element name="TeradataUsIncMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_TeradataUsIncMember" substitutionGroup="xbrli:item" />
  <element id="iova_LeaseExpirationTerm" name="LeaseExpirationTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element name="OfficeSpaceMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_OfficeSpaceMember" substitutionGroup="xbrli:item" />
  <element name="StevenFischkoffMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_StevenFischkoffMember" substitutionGroup="xbrli:item" />
  <element id="iova_CommonStockRegisteredForResale" name="CommonStockRegisteredForResale" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_SharesSoldUnderIneffectiveRegistration" name="SharesSoldUnderIneffectiveRegistration" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element name="NumberOfShareOptionsOrShareUnitsExercisedDuringCurrentPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="iova_NumberOfShareOptionsOrShareUnitsExercisedDuringCurrentPeriod" substitutionGroup="xbrli:item" />
  <element id="iova_SeverancePayAndRetentionBonus" name="SeverancePayAndRetentionBonus" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element name="TwentyElevenEquityIncentivePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_TwentyElevenEquityIncentivePlanMember" substitutionGroup="xbrli:item" />
  <element id="iova_PaymentsForLegalServices" name="PaymentsForLegalServices" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element name="ConsultingAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_ConsultingAgreementMember" substitutionGroup="xbrli:item" />
  <element id="iova_ScheduleOfUsefulLivesOfPropertyPlantAndEquipmentTableTextBlock" name="ScheduleOfUsefulLivesOfPropertyPlantAndEquipmentTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_NumberOfFinancialInstitutions" name="NumberOfFinancialInstitutions" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_ShareBasedCompensationMaximumAwardPerPerson" name="ShareBasedCompensationMaximumAwardPerPerson" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_NumberOfIndicationsUnderAgreement" name="NumberOfIndicationsUnderAgreement" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_NotificationPeriodToTerminateAgreement" name="NotificationPeriodToTerminateAgreement" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_NumberOfClinicalTrials" name="NumberOfClinicalTrials" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_NumberOfSuitesUnderAgreement" name="NumberOfSuitesUnderAgreement" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_NumberOfStatementsOfWork" name="NumberOfStatementsOfWork" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_ClassActionSuitsAllegingViolationOfFederalSecuritiesLawsMember" name="ClassActionSuitsAllegingViolationOfFederalSecuritiesLawsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_SolomonCapitalLlcLitigationMember" name="SolomonCapitalLlcLitigationMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_AdditionalMilestonePayable" name="AdditionalMilestonePayable" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="iova_ProceedsFromIssuanceOfCommonAndPreferredStock" name="ProceedsFromIssuanceOfCommonAndPreferredStock" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="iova_ConvertiblePreferredStockNumberOfSharesOfCommonStockAvailableUponConversionTotal" name="ConvertiblePreferredStockNumberOfSharesOfCommonStockAvailableUponConversionTotal" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <element id="iova_SupplementalBalanceSheetInformationRelatedToLeasesTableTextBlock" name="SupplementalBalanceSheetInformationRelatedToLeasesTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_RestrictedCommonStockMember" name="RestrictedCommonStockMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_OperatingLeaseLiabilityAbstract" name="OperatingLeaseLiabilityAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_CmoEmbeddedLeasesMember" name="CmoEmbeddedLeasesMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_OperatingLeasePresentValueAdjustments" name="OperatingLeasePresentValueAdjustments" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <element id="iova_NonCashLeaseExpense" name="NonCashLeaseExpense" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="iova_StockCancelledDuringPeriodSharesOfCommonStock" name="StockCancelledDuringPeriodSharesOfCommonStock" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="iova_ResearchCollaborationAndClinicalGrantAgreementsWithMoffittMember" name="ResearchCollaborationAndClinicalGrantAgreementsWithMoffittMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_CancellationOfCommonSharesFromSettlementOfDisputeInShares" name="CancellationOfCommonSharesFromSettlementOfDisputeInShares" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_ScheduleOfCashAndCashEquivalentsAndRestrictedCashTableTextBlock" name="ScheduleOfCashAndCashEquivalentsAndRestrictedCashTableTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_IncreaseDecreaseInOperatingLeaseRightOfUseAssets" name="IncreaseDecreaseInOperatingLeaseRightOfUseAssets" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="iova_IncreaseDecreaseInOperatingLeaseLiabilities" name="IncreaseDecreaseInOperatingLeaseLiabilities" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="iova_PhiladelphiaOfficeLeaseForFirstYearMember" name="PhiladelphiaOfficeLeaseForFirstYearMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_PhiladelphiaOfficeLeaseForNextThreeYearsMember" name="PhiladelphiaOfficeLeaseForNextThreeYearsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_CommercialManufacturingFacilityAgreementMember" name="CommercialManufacturingFacilityAgreementMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_CommercialManufacturingFacilityAgreementForPhaseIMember" name="CommercialManufacturingFacilityAgreementForPhaseIMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_CommercialManufacturingFacilityAgreementForPhaseIBMember" name="CommercialManufacturingFacilityAgreementForPhaseIBMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_PeriodOfSubstantialCompletionForPhaseI" name="PeriodOfSubstantialCompletionForPhaseI" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_PriorWrittenNoticePeriodToLandlord" name="PriorWrittenNoticePeriodToLandlord" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_MinimumOperatingLeasesOfLesseeContingentRentalsBasisSpreadOnVariableRateAverageTenYearConsumerPriceIndex" name="MinimumOperatingLeasesOfLesseeContingentRentalsBasisSpreadOnVariableRateAverageTenYearConsumerPriceIndex" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_MaximumOperatingLeasesOfLesseeContingentRentalsBasisSpreadOnVariableRateAverageTenYearConsumerPriceIndex" name="MaximumOperatingLeasesOfLesseeContingentRentalsBasisSpreadOnVariableRateAverageTenYearConsumerPriceIndex" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_AdditionalAreaOfSpaceUnderAmendedLease" name="AdditionalAreaOfSpaceUnderAmendedLease" nillable="true" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_NumberOfPhases" name="NumberOfPhases" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_PeriodOfConsultingAgreement" name="PeriodOfConsultingAgreement" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_IncreaseDecreaseInOperatingLeaseRightOfUseAsset" name="IncreaseDecreaseInOperatingLeaseRightOfUseAsset" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <element id="iova_AggregateIntrinsicValueAbstract" name="AggregateIntrinsicValueAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_AccountingPoliciesTable" name="AccountingPoliciesTable" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" xbrli:periodType="duration" />
  <element id="iova_AccountingPoliciesLineItems" name="AccountingPoliciesLineItems" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_CommonStockIssuedFromPreferredStockConversion" name="CommonStockIssuedFromPreferredStockConversion" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <element id="iova_CommonStockIssuedFromPreferredStockConversionShares" name="CommonStockIssuedFromPreferredStockConversionShares" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_RestrictedCashPolicyTextBlock" name="RestrictedCashPolicyTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <element id="iova_DeferredTaxAssetsDepreciationAndAmortization" name="DeferredTaxAssetsDepreciationAndAmortization" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <element id="iova_DeferredTaxAssetsLeaseLiabilities" name="DeferredTaxAssetsLeaseLiabilities" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <element id="iova_QuarterlyFixedFeesPayableForEachDedicatedManufacturingSuites" name="QuarterlyFixedFeesPayableForEachDedicatedManufacturingSuites" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <element id="iova_MedimmuneAgreementMember" name="MedimmuneAgreementMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <element id="iova_AshCashEquivalentsAndShortTermInvestmentsAndRestrictedCashTotal" name="AshCashEquivalentsAndShortTermInvestmentsAndRestrictedCashTotal" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <element id="iova_EffectiveIncomeTaxRateReconciliationExpectedRateTotal1" name="EffectiveIncomeTaxRateReconciliationExpectedRateTotal1" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
</schema>
