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  <xsd:element id="iova_Rightofuseassetobtainedinexchangeforoperatingleaseliabilityfromnewleases" name="Rightofuseassetobtainedinexchangeforoperatingleaseliabilityfromnewleases" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element name="UtilityEquipmentMember" id="iova_UtilityEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TenantImprovementAllowanceReimbursementReceived" id="iova_TenantImprovementAllowanceReimbursementReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CashCashEquivalentsInvestmentsAndFairValueMeasurementsAbstract" id="iova_CashCashEquivalentsInvestmentsAndFairValueMeasurementsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RestrictedStockUnitsRsusAndPerformanceBasedRestrictedStockUnitsPrsusMember" id="iova_RestrictedStockUnitsRsusAndPerformanceBasedRestrictedStockUnitsPrsusMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LetterOfCreditForCommercialManufacturingFacilityMember" id="iova_LetterOfCreditForCommercialManufacturingFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LetterOfCreditForBenefitOfLandlordForHeadquartersLeaseMember" id="iova_LetterOfCreditForBenefitOfLandlordForHeadquartersLeaseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DecreaseInLettersOfCreditOnLeaseExpiration" id="iova_DecreaseInLettersOfCreditOnLeaseExpiration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="MinimumRestrictedSecurityDeposit" id="iova_MinimumRestrictedSecurityDeposit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="SponsoredResearchAgreementMember" id="iova_SponsoredResearchAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AdjustmenttoAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationNetShares" id="iova_AdjustmenttoAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationNetShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CollaborationArrangementTerminationNoticePeriodBeforeRegulatoryApproval" id="iova_CollaborationArrangementTerminationNoticePeriodBeforeRegulatoryApproval" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="FirstWuxiManufacturingAndServicesAgreementMember" id="iova_FirstWuxiManufacturingAndServicesAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SecondWuxiManufacturingAndServicesAgreementMember" id="iova_SecondWuxiManufacturingAndServicesAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AdjustmentToAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationsNet" id="iova_AdjustmentToAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationsNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="FirstSalesAgreementMember" id="iova_FirstSalesAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SecondSalesAgreementMember" id="iova_SecondSalesAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsVestedAndExpectedToVestOutstandingNumber" id="iova_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsVestedAndExpectedToVestOutstandingNumber" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsVestedAndExpectedToVestOutstandingWeightedAverageGrantDateFairValue" id="iova_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsVestedAndExpectedToVestOutstandingWeightedAverageGrantDateFairValue" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="CollaborationArrangementPeriodToAddressIssuesWithinReceiptOfResponseLetter" id="iova_CollaborationArrangementPeriodToAddressIssuesWithinReceiptOfResponseLetter" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PerformanceBasedRestrictedStockUnitMember" id="iova_PerformanceBasedRestrictedStockUnitMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DeferredTaxAssetsCapitalizedResearchAndDevelopment" id="iova_DeferredTaxAssetsCapitalizedResearchAndDevelopment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="OptionAgreementMember" id="iova_OptionAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ClinigenHealthcareLimitedAndClinigenIncMember" id="iova_ClinigenHealthcareLimitedAndClinigenIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CollaborationAgreementUpfrontPayments" id="iova_CollaborationAgreementUpfrontPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="MilestonePayableOnApproval" id="iova_MilestonePayableOnApproval" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="NumberOfStatementsOfWorkUnderAgreement" id="iova_NumberOfStatementsOfWorkUnderAgreement" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
</xsd:schema>
