Document And Entity Information
Document Information [Table]
Document Information [Line Items]
Document Type
Document Annual Report
Document Period End Date
Document Transition Report
Entity File Number
Entity Registrant Name
Entity Incorporation, State or Country Code
Entity Tax Identification Number
Entity Address, Address Line One
Entity Address, City or Town
Entity Address, State or Province
Entity Address, Postal Zip Code
City Area Code
Local Phone Number
Entity Current Reporting Status
Entity Interactive Data Current
Entity Filer Category
Entity Small Business
Entity Emerging Growth Company
Document Financial Statement Error Correction [Flag]
Entity Shell Company
Title of 12(b) Security
Trading Symbol
Security Exchange Name
Entity Common Stock, Shares Outstanding
Entity Well-known Seasoned Issuer
Entity Voluntary Filers
ICFR Auditor Attestation Flag
Entity Public Float
Auditor Name
Auditor Firm ID
Auditor Location
Entity Central Index Key
Current Fiscal Year End Date
Document Fiscal Year Focus
Document Fiscal Period Focus
Amendment Flag
Consolidated Balance Sheets
Statement [Table]
Class of Stock [Axis]
Class of Stock [Domain]
Series A Convertible Preferred Stock
Series B Convertible Preferred Stock
Series B Convertible Preferred Stock
Statement [Line Items]
Company's equity incentive plans
Statement
Assets [Abstract]
ASSETS
Assets, Current [Abstract]
Current Assets
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents
Cash and cash equivalents
Accounts Receivable, after Allowance for Credit Loss, Current
Trade accounts receivable
Short-term investments
Short-term investments
Inventory, Net
Inventory
Total inventory
Prepaid Expense and Other Assets, Current
Prepaid expenses and other assets
Assets, Current
Total Current Assets
Property and equipment, net
Property, Plant and Equipment, Net
Property and equipment, net
Finite-Lived Intangible Assets, Net
Intangible assets, net
Operating Lease, Right-of-Use Asset
Operating lease right-of-use assets
Restricted Cash, Noncurrent
Restricted cash
Other Assets, Noncurrent
Long-term assets
Assets
Total Assets
Liabilities and Equity [Abstract]
LIABILITIES AND STOCKHOLDERS' EQUITY
Liabilities, Current [Abstract]
Current Liabilities
Accounts Payable, Current
Accounts payable
Accrued Liabilities and Other Liabilities
Accrued expenses and other liabilities
Operating Lease, Liability, Current
Operating lease liabilities
Current portion included in current liabilities
Liabilities, Current
Total Current Liabilities
Liabilities, Noncurrent [Abstract]
Non-Current Liabilities
Operating Lease, Liability, Noncurrent
Operating lease liabilities - non-current
Long-term portion included in non-current liabilities
Deferred Income Tax Liabilities, Net
Deferred tax liabilities
Notes Payable, Noncurrent
Long-term note payable
Liabilities, Noncurrent
Total Non-Current Liabilities
Liabilities
Total Liabilities
Commitments and Contingencies
Commitments and contingencies
Consolidated Statements of Stockholders' Equity
Stockholders' Equity
Preferred Stock, Value, Issued
Preferred stock, Value
Common Stock, Value, Issued
Common stock, $0.000041666 par value; 500,000,000 shares authorized, 305,252,194 and 256,135,715 shares issued and outstanding as of December 31, 2024 and December 31, 2023, respectively
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive loss (income)
Additional Paid in Capital
Additional paid-in capital
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Stockholders' Equity Attributable to Parent
Ending Balance
Beginning Balance
Total Stockholders' Equity
Liabilities and Equity
Total Liabilities and Stockholders' Equity
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par or stated value per share
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Preferred Stock, Shares Issued
Preferred Stock, Shares Issued
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Common Stock, Par or Stated Value Per Share
Common stock, par or stated value per share
Common Stock, Shares Authorized
Common stock, shares authorized
Common Stock, Shares, Issued
Common Stock, Shares, Issued
Common stock, shares issued
Common Stock, Shares, Outstanding
Common Stock, Shares, Outstanding
Common stock, shares outstanding
Consolidated Statements of Operations
Revenue from Contract with Customer, Excluding Assessed Tax
Total net revenue
Net revenue
Net sales
Revenue from Contract with Customer, Product and Service [Extensible Enumeration]
Operating Expenses [Abstract]
Expenses
Costs and expenses
Cost of Revenue
Cost of sales
Total cost of sales
Research and Development Expense
Research and development
Research and development
General and Administrative Expense
General and administrative
Selling, general and administrative
Costs and Expenses
Total costs and expenses
Operating Income (Loss)
Loss from operations
Nonoperating Income (Expense) [Abstract]
Other income
Investment Income, Interest
Interest and other income, net
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Net Loss before income taxes
Income Tax Expense (Benefit)
Income tax benefit
Net Loss
Net Loss
Net Loss
Earnings Per Share, Basic
Net Loss Per Share of Common Stock, Basic
Earnings Per Share, Diluted
Net Loss Per Share of Common Stock, Diluted
Weighted Average Number of Shares Outstanding, Basic
Weighted Average Shares of Common Stock Outstanding, Basic
Weighted Average Number of Shares Outstanding, Diluted
Weighted Average Shares of Common Stock Outstanding, Diluted
Consolidated Statements of Comprehensive Loss
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Other comprehensive loss:
Other Comprehensive Income (Loss), Securities, Available-for-Sale, Unrealized Holding Gain (Loss) Arising During Period, after Tax
Unrealized gain on investments
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax
Foreign currency translation adjustment
Foreign currency cumulative translation adjustment
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive Loss
Equity Components [Axis]
Equity Component [Domain]
Preferred Stock
Common Stock
Common Stock
Additional Paid-In Capital
Accumulated Other Comprehensive Income
Accumulated Deficit
Shares, Outstanding
Ending Balance (in Shares)
Beginning Balance (in Shares)
Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition
Stock-based compensation expense
Stock Issued During Period, Value, Employee Stock Purchase Plan
Common stock issued upon purchase of employee stock purchase plan
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Common stock issued upon purchase of employee stock purchase plan (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
Vesting of restricted shares issued for services (in shares)
Amount of increase (decrease) in additional paid in capital (APIC) resulting from a tax benefit (deficiency) associated with an share-based compensation plan other than an employee stock ownership plan (ESOP).
Adjustment to Additional Paid in Capital, Income Tax Effect from Share-Based Compensations, Net
Tax payments related to shares retired for vested restricted stock units
Shares increase (decrease) in additional paid in capital
(APIC) resulting from a tax benefit (deficiency) associated with
an share-based compensation plan other than an employee
stock ownership plan (ESOP).
Adjustments To Additional Paid In Capital Income Tax Effect From Share Based Compensation Net Shares
Tax payments related to shares retired for vested restricted stock units (in shares)
Stock Issued During Period, Shares, New Issues
Common stock sold in public and/or at the market offering, net of offering costs (in shares)
Common stock sold in public offering
Stock Issued During Period, Value, Other
Common stock sold in public and/or at the market offering, net of offering costs
Stock Issued During Period, Shares, Other
Common stock sold in public and/or at the market offering, net of offering costs (in shares)
Stock Issued During Period, Value, Stock Options Exercised
Common stock issued upon exercise of stock options
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Exercised
Common stock issued upon exercise of stock options (in shares)
Consolidated Statements of Cash Flows
Net Cash Provided by (Used in) Operating Activities [Abstract]
Cash Flows from Operating Activities
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based Compensation
Stock-based compensation expense
Gain (Loss), Foreign Currency Transaction, before Tax
Unrealized foreign exchange gains
Amortization of Intangible Assets
Amortization of intangible assets
Amortization expense
Operating Lease, Right-of-Use Asset, Amortization Expense
Amortization of right of use asset
Depreciation, Depletion and Amortization, Nonproduction
Depreciation and amortization expense
Depreciation and amortization of property and equipment
Deferred Income Tax Expense (Benefit)
Deferred tax benefit
Accretion (Amortization) of Discounts and Premiums, Investments
Accretion of discounts and premiums on investments
Impairment of Long-Lived Assets Held-for-use
Impairment of long-lived assets
Gain (Loss) on Termination of Lease
Gain on derecognition of lease assets and liabilities
Gain on termination of lease
Increase (Decrease) in Operating Capital [Abstract]
Changes in assets and liabilities:
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses, other assets and long-term assets
Increase (Decrease) in Accounts Receivable
Trade accounts receivable
Increase (Decrease) in Inventories
Inventory
Increase (Decrease) in Operating Lease Liability
Operating lease liabilities
Increase (Decrease) in Accounts Payable
Accounts payable
Increase (Decrease) in Accrued Liabilities
Accrued expenses and other liabilities
Net Cash Provided by (Used in) Operating Activities
Net cash used in operating activities
Net cash used in operating activities
Net Cash Provided by (Used in) Investing Activities [Abstract]
Cash Flows from Investing Activities
Proceeds from Sale and Maturity of Debt Securities, Available-for-sale
Maturities of investments
Payments to Acquire Available-for-sale Securities
Purchase of investments
The cash outflow associated with the acquisition of asset including contingent consideration, net of the cash acquired from the purchase.
Payments for Asset Acquisition Including Contingent Consideration, Net of Cash Acquired
Cash paid for acquisition, including contingent consideration, net of cash acquired
Payments to Acquire Property, Plant, and Equipment
Purchase of property and equipment
Net Cash Provided by (Used in) Investing Activities
Net cash used in investing activities
Net Cash Provided by (Used in) Financing Activities [Abstract]
Cash Flows from Financing Activities
Payments Related to Tax Withholding for Share-based Compensation
Tax payments related to shares withheld for vested restricted stock units
The cash inflow from the additional capital contribution to the entity under Employee Stock Purchase Plan.
Proceeds from Issuance of Common Stock, Under Employee Stock Purchase Plan
Proceeds from the issuance of common stock under employee stock purchase plan
Proceeds from Stock Options Exercised
Proceeds from the issuance of common stock upon exercise of options
Proceeds from Issuance of Common Stock
Proceeds from the issuance of common stock, net
Net Cash Provided by (Used in) Financing Activities
Net cash provided by financing activities
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Continuing Operations
Effect of foreign exchange rate changes
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Net increase in cash, cash equivalents and restricted cash
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents
Cash, Cash Equivalents and Restricted Cash End of Period
Cash, Cash Equivalents and Restricted Cash Beginning of Period
Total cash, cash equivalents and restricted cash
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Supplemental disclosure of non-cash investing and financing activities:
Fair Value of Assets Acquired
Fair value of net assets acquired
Unrealized Gain (Loss) on Investments
Net unrealized gain on investments
The amount of acquisitions of property and equipment included in accounts payable and accrued expense.
Acquisitions Of Property And Equipment Included In Accounts Payable And Accrued Expense
Acquisition of property and equipment included in accounts payable and accrued expenses
Noncash or Part Noncash Acquisition, Intangible Assets Acquired
Intangible asset and deferred tax liability arising from contingent consideration
Amount of increase in right-of-use asset obtained in exchange for operating lease liability from new leases.
RightOfUseAssetObtainedInExchangeForOperatingLeaseLiabilityFromNewLeases
Lease liabilities arising from obtaining right-of-use asset from new leases
Amount of increase in right-of-use asset obtained in exchange for operating lease liability from lease modifications.
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability From Lease Modifications
Lease liabilities arising from obtaining right-of-use asset from lease modifications
GENERAL ORGANIZATION, BUSINESS AND LIQUIDITY
Business Description and Basis of Presentation [Text Block]
GENERAL ORGANIZATION, BUSINESS AND LIQUIDITY
SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES
Significant Accounting Policies [Text Block]
SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES
N/A.
CASH EQUIVALENTS AND INVESTMENTS
Cash, Cash Equivalents, and Short-term Investments [Text Block]
CASH EQUIVALENTS AND INVESTMENTS
PROLEUKIN ACQUISITION
Asset Acquisition [Text Block]
PROLEUKIN ACQUISITION
INTANGIBLE ASSETS, NET
Intangible Assets Disclosure [Text Block]
INTANGIBLE ASSETS, NET
INVENTORY
Inventory Disclosure [Text Block]
INVENTORY
REVENUE
Revenue from Contract with Customer [Text Block]
REVENUE
PROPERTY AND EQUIPMENT, NET
Property, Plant and Equipment Disclosure [Text Block]
PROPERTY AND EQUIPMENT, NET
ACCRUED EXPENSES
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
ACCRUED EXPENSES
STOCKHOLDERS' EQUITY
Stockholders' Equity Note Disclosure [Text Block]
STOCKHOLDERS' EQUITY
SEGMENT INFORMATION
Segment Reporting Disclosure [Text Block]
SEGMENT INFORMATION
EMPLOYEE BENEFIT PLAN
Compensation and Employee Benefit Plans [Text Block]
EMPLOYEE BENEFIT PLAN
INCOME TAXES
Income Tax Disclosure [Text Block]
INCOME TAXES
LICENSES AND AGREEMENTS
The entire disclosure for licenses and agreements.
Licenses And Agreements Disclosure [Text Block]
LICENSES AND AGREEMENTS
LEASES
Lessee, Operating Leases [Text Block]
LEASES
LEGAL PROCEEDINGS
Contingencies Disclosure [Text Block]
LEGAL PROCEEDINGS
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash, Cash Equivalents, and Investments
Disclosure of accounting policy for restricted cash.
Restricted Cash [Policy Text Block]
Restricted Cash
Business Combinations Policy [Policy Text Block]
Asset Acquisitions
Disclosure of inventory and cost of sales accounting policy.
Inventories and Cost of Sales [Policy Text Block]
Inventory and Cost of Sales
Accounts Receivable [Policy Text Block]
Trade Accounts Receivable
Goodwill and Intangible Assets, Intangible Assets, Policy [Policy Text Block]
Intangible Assets
Lessee, Leases [Policy Text Block]
Leases
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment, net
Fair Value Measurement, Policy [Policy Text Block]
Fair Value Measurements
Revenue from Contract with Customer [Policy Text Block]
Revenue Recognition
Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block]
Stock-Based Compensation
Research and Development Expense, Policy [Policy Text Block]
Accrued Research and Development Costs
Selling, General and Administrative Expenses, Policy [Policy Text Block]
Selling, general and administrative expense
Income Tax, Policy [Policy Text Block]
Income Taxes
Earnings Per Share, Policy [Policy Text Block]
Net Loss per Share
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Consolidation, Policy [Policy Text Block]
Principles of Consolidation
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Foreign Currency Translation
Segment Reporting, Policy [Policy Text Block]
Segment Reporting
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentrations
New Accounting Pronouncements, Policy [Policy Text Block]
Recent Accounting Standards
Tabular disclosure of the components of cash, cash equivalents and Restricted Cash.
Schedule of Cash and Cash Equivalents and Restricted Cash [Table Text Block]
Schedule of cash and cash equivalents and restricted cash
Tabular disclosure of useful lives of categories of property, plant and equipment.
Schedule Of Useful Lives Of Property Plant And Equipment [Table Text Block]
Schedule Of Useful Lives Of Property Plant And Equipment
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Antidilutive securities excluded from computation of earnings per share
Unrealized Gain (Loss) on Investments [Table Text Block]
Schedule of cost and fair value of cash equivalents and short-term investments
Debt Securities, Available-for-sale [Table Text Block]
Schedule of available-for-sale debt securities
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Schedule of fair value of the company's financial assets
Asset Acquisition [Table Text Block]
Summary of the total cash consideration and allocated acquisition date fair values of assets acquired and liabilities assumed
Schedule of Finite-Lived Intangible Assets [Table Text Block]
Summary of gross carrying amounts and net book value of intangible assets
Schedule of Inventory, Current [Table Text Block]
Summary of inventories
Disaggregation of Revenue [Table Text Block]
Schedule of disaggregation of revenue by product
Tabular disclosure for gross to net adjustments recorded in revenue.
Schedule Of Gross to Net Adjustments in Revenue [Table Text Block]
Schedule of GTN adjustments recorded in revenue
Schedules of Concentration of Risk, by Risk Factor [Table Text Block]
Schedule of the amount and percentage of gross revenue attributable to customers that represented more than 10% of the Company's gross revenue and all other customers as a group
Property, Plant and Equipment [Table Text Block]
Schedule of Property and equipment
Schedule of Accrued Liabilities [Table Text Block]
Schedule of accrued expenses
Share-based Compensation, Stock Options, Activity [Table Text Block]
Schedule of status of stock options
Share-based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Schedule of summary of RSU activity including PRSUs
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
Schedule of stock-based compensation
Schedule of Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Table Text Block]
Schedule of stock-based compensation by type of award
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of share-based payment award, stock options, valuation assumptions
Reconciliation of Operating Profit (Loss) from Segments to Consolidated [Table Text Block]
Summary of company's revenue, expenses and net loss for the segment and is reconciled to net loss on a consolidated basis
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Deferred Tax Assets and Liabilities
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Effective Income Tax Rate Reconciliation
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Schedule of Unrecognized Tax Benefits
Tabular disclosure of supplemental balance sheet information related to leases
Supplemental Balance Sheet Information Related To Leases [Table Text Block]
Schedule of balance sheet classification of the Company's right-of-use asset and lease liabilities
Lease, Cost [Table Text Block]
Schedule of components of lease expenses
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Schedule of minimum lease commitments
Subsequent Event Type [Axis]
Subsequent Event Type [Domain]
Subsequent Event [Member]
Subsequent Event
Range [Axis]
Range [Domain]
Minimum
Minimum
Product and Service [Axis]
Product and Service [Domain]
Represents the information pertaining to Amtagvi (lifileucel), the first product within its autologous TIL cell therapy platform.
Amtagvi [Member]
Amtagvi
Represents the number of patients that can be treated annually.
Number Of Patients To Be Treated Annually
Number of patients to be treated annually
Cash includes currency on hand as well as demand deposits with banks or financial institutions. It also includes other kinds of accounts that have the general characteristics of demand deposits in that the customer may deposit additional funds at any time and effectively may withdraw funds at any time without prior notice or penalty. Cash equivalents, excluding items classified as marketable securities, include short-term, highly liquid Investments that are both readily convertible to known amounts of cash, and so near their maturity that they present minimal risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify under that definition. Original maturity means original maturity to the entity holding the investment. For example, both a three-month US Treasury bill and a three-year Treasury note purchased three months from maturity qualify as cash equivalents. However, a Treasury note purchased three years ago does not become a cash equivalent when its remaining maturity is three months. Short-term investments, exclusive of cash equivalents, generally consist of marketable securities intended to be sold within one year (or the normal operating cycle if longer) and may include trading securities, available-for-sale securities, or held-to-maturity securities (if maturing within one year), as applicable.
Cash, Cash Equivalents and Short-term Investments and Restricted Cash Total
Cash, cash equivalents, short-term investments, and restricted cash
Restricted Cash
Restricted cash
Restricted cash (current and long-term)
Proceeds from Issuance or Sale of Equity
Proceeds from Issuance of sale
Disclosure of information about significant accounting policies.
Accounting Policies [Table]
Restricted Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents [Domain]
Represents the cash restricted for the benefit of the landlord
for its commercial manufacturing facility.
Commercial manufacturing facility
Represents the cash restricted for the benefit of the landlord for headquarters lease.
Headquarters lease
Maximum
Maximum
Asset Acquisition [Axis]
Asset Acquisition [Domain]
Represents the information pertaining to Proleukin (aldesleukin), product used in the Amtagvi treatment regimen.
PROLEUKIN [Member]
PROLEUKIN
Proleukin
Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES.
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
Amount of impairment of investment in debt security, measured at amortized cost (held-to-maturity), charged against allowance for credit loss.
Debt Securities, Available-for-Sale, Allowance for Credit Loss, Impairment Loss
Impairment losses related to credit losses
Security Deposit
Security deposit
Amount of minimum restricted security deposit to be maintained.
Minimum Restricted Security Deposit
Restricted security deposit
Represents the security deposit for future milestone payment in asset acquisition.
Security Deposit For Future Milestone Payment in Asset Acquisition
Future milestone payment
The cash outflow for payment of contingent consideration associated with the asset acquisition.
Payments of Contingent Consideration for Asset Acquisition
Contingent consideration paid for acquisition
The amount of decrease in letters of credit on lease expiration.
Decrease in Letters of Credit on Lease Expiration
Decrease in letters of credit
The payment term of customers.
Customer Payment Term
Customer payment term
Property, Plant and Equipment, Type [Axis]
Property, Plant and Equipment, Type [Domain]
Computer equipment
Computer equipment
Computer software
Computer software
Office furniture and equipment
Office furniture and equipment
Lab, process, and validation equipment
Lab, process, and validation equipment
Machinery and equipment
Machinery and equipment
Represents information pertaining to utility equipment.
Utility equipment
Utility equipment
Leasehold improvements
Leasehold improvements
Property, Plant and Equipment, Useful Life
Property, Plant and Equipment, Estimated Useful Lives
Antidilutive Securities [Axis]
Antidilutive Securities, Name [Domain]
Stock option expense
Restricted stock units
Restricted stock units
Restricted stock expense
Represents information pertaining to employee stock purchase plan.
Employee Stock Purchase Plan
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Antidilutive securities excluded from calculation of net loss per share
Number of Operating Segments
Number of operating segment
Number of operating segments
The number of financial institutions at which the entity maintains balances.
Number Of Financial Institutions
Income Tax Examination, Penalties and Interest Expense
Interest or penalties on unpaid tax
Interest and penalties
Financial Instrument [Axis]
Financial Instruments [Domain]
U.S. treasury securities
Money market funds
Available-for-sale Securities, Amortized Cost Basis
Amortized Cost
Available-for-sale Securities, Accumulated Gross Unrealized Gain, before Tax
Gross Unrealized Gains
Available-for-sale Securities
Total investments
Fair Value
Schedule of Cash and Cash Equivalents [Table]
Cash and Cash Equivalents [Line Items]
Cash Equivalents, at Carrying Value
Cash equivalents total
Cash equivalents
Debt Securities, Available-for-sale, Current
Short-term investments
Cash and Cash Equivalents [Axis]
Demand Deposits
Debt Securities, Available-for-sale, Unrealized Loss
Unrealized losses on available-for-sale
Debt Securities, Available-for-sale, Continuous Unrealized Loss Position, 12 Months or Longer, Number of Positions
Number of investments in debt securities in continuous unrealized loss position for more than 12 months
Measurement Frequency [Axis]
Fair Value, Measurement Frequency [Domain]
Recurring
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV [Domain]
Level 1
Assets, Fair Value Disclosure
Total
Asset Acquisition [Table]
Asset Acquisition [Line Items]
PROLEUKIN ACQUISITION
Payments to Acquire Productive Assets
Upfront payment
Cash payment
The payments for certain inventory using existing cash on hand in an asset acquisition.
Asset Acquisition, Payment for Certain Inventory
Payment for certain inventory
Finite-Lived Intangible Assets by Major Class [Axis]
Finite-Lived Intangible Assets, Major Class Name [Domain]
Developed technology
Developed technology
Represents the assembled workforce acquired in an asset acquisition.
Assembled Workforce [Member]
Assembled workforce
Asset Acquisition, Consideration Transferred [Abstract]
Total cash consideration and allocated acquisition date fair values of assets acquired and liabilities assumed
Amount of currency on hand acquired at the acquisition date in an asset acquisition.
Asset Acquisition, Recognized Identifiable Assets Acquired and Liabilities Assumed, Cash
Cash
The amount of inventory recognized in an asset acquisition.
Asset Acquisition, Recognized Identifiable Assets Acquired and Liabilities Assumed, Inventory
Inventory
The amount of identifiable intangible assets recognized in an asset acquisition.
Asset Acquisition, Recognized Identifiable Assets Acquired and Liabilities Assumed, Intangibles
Intangible assets
Amount of deferred tax liability attributable to taxable temporary differences assumed in an asset acquisition.
Asset Acquisition, Recognized Identifiable Assets Acquired and Liabilities Assumed, Deferred tax liability
Deferred tax liability
Asset Acquisition, Consideration Transferred
Total cost of acquisition
Total Cost of Acquisition
Income Statement Location [Axis]
Income Statement Location [Domain]
Selling, General and Administrative Expenses [Member]
Selling, general and administrative
Asset Acquisition, Consideration Transferred, Transaction Cost
Direct transaction costs incurred
Asset Acquisition, Consideration Transferred, Contingent Consideration
Contingent cash payments, milestone payment
Represents the deferred consideration term for completion of the Acquisition.
Asset Acquisition, Deferred consideration term
Deferred consideration term
Finite-Lived Intangible Assets Acquired
Finite-lived intangible assets
Finite-Lived Intangible Asset, Useful Life
Expected useful life of intangible assets
Acquired Finite-Lived Intangible Assets, Weighted Average Useful Life
Weighted average amortization period
Schedule of Finite-Lived Intangible Assets [Table]
Intellectual Property [Member]
Intellectual property license
Finite-Lived Intangible Assets [Line Items]
INTANGIBLE ASSETS, NET
Finite-Lived Intangible Assets, Net [Abstract]
Gross carrying amounts and net book value of intangible assets
Finite-Lived Intangible Assets, Gross
Gross carrying amounts
Finite-Lived Intangible Assets, Accumulated Amortization
Less: accumulated amortization
Finite-Lived Intangible Assets, Net, Amortization Expense, Fiscal Year Maturity [Abstract]
Total estimated amortization of the Company's intangible assets:
Finite-Lived Intangible Asset, Expected Amortization, Year One
Year ending December 31, 2025
Finite-Lived Intangible Asset, Expected Amortization, Year Two
Year ending December 31, 2026
Finite-Lived Intangible Asset, Expected Amortization, Year Three
Year ending December 31, 2027
Finite-Lived Intangible Asset, Expected Amortization, Year Four
Year ending December 31, 2028
Finite-Lived Intangible Asset, Expected Amortization, Year Five
Years ending December 31, 2029
Inventory, Net [Abstract]
INVENTORY
Inventory, Raw Materials, Net of Reserves
Raw materials
Inventory, Work in Process, Net of Reserves
Work in process
Inventory, Finished Goods, Net of Reserves
Finished goods
Disaggregation of Revenue [Table]
Disaggregation of Revenue [Line Items]
REVENUE
Amount, before adjustments, of revenue from satisfaction of performance obligation by transferring promised good or service to customer.
Revenue From Contract With Customer, Gross
Gross revenue
Gross revenue
n/a
Revenue From Contract with Customer, Gross to Net Adjustments [Abstract]
GTN adjustments:
Amount of adjustments to revenue from contract from customer for Government rebates and chargebacks.
Adjustments For Government Rebates And Chargebacks
Government rebates and chargebacks
Amount of adjustments to revenue from contract from customer for wholesaler fees and cash discounts.
Adjustments For Wholesaler Fees And Cash Discounts
Wholesaler fees and cash discounts
Amount of adjustments to revenue from contract from customer for other rebates, returns, discounts and adjustments.
Adjustments For Other Rebates, Returns, Discounts And Adjustments
Other rebates, returns, discounts and adjustments
Amount of adjustments from gross revenues to net revenues from contract with customers.
Revenue From Contract With Customer, Gross To Net Adjustments
GTN adjustments
Total GTN adjustments
Geographical [Axis]
Geographical [Domain]
UNITED STATES
United States
Non-US
Rest of world
For an entity that discloses threshold for concentration of credit risk of customers.
Threshold For Concentration Of Credit Risk
Threshold for concentration of credit risk
Concentration Risk [Table]
Concentration Risk Benchmark [Axis]
Concentration Risk Benchmark [Domain]
Revenue from Contract with Customer Benchmark [Member]
Revenue
Concentration Risk Type [Axis]
Concentration Risk Type [Domain]
Customer Concentration Risk [Member]
Customer concentration
Customer [Axis]
Customer [Domain]
Represents information pertaining to Customer A.
Customer A [Member]
Customer A
Represents information pertaining to other customers.
Other Customers [Member]
Other customers
Concentration Risk [Line Items]
Summary of the amount and percentage of gross revenue attributable to customers that represented more than 10% of the Company's gross revenue and all other customers as a group
Concentration Risk, Percentage
Concentration risk (in percent)
Property, Plant and Equipment [Table]
Construction in progress
Construction in progress
Property, Plant and Equipment [Line Items]
PROPERTY AND EQUIPMENT, NET
Property, Plant and Equipment, Gross
Total property and equipment, cost
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less: Accumulated depreciation and amortization
Lease Contractual Term [Axis]
Lease Contractual Term [Domain]
Represents information relating to New Headquarters Lease.
New Headquarters Lease
New Headquarters Lease
This member stands for San Carlos, California.
San Carlos, California
San Carlos, California
Office Space
Office Space
The aggregate amount of write-downs for impairments recognized during the period for long lived assets due to early termination of lease.
Impairment of Long-lived Assets Due to Early Termination of Lease
Impairment due to early termination
Accrued Employee Benefits, Current
Accrued payroll and employee related expenses
Carrying value as of the balance sheet date of obligations incurred through that date and payable for clinical and related services. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Clinical Related Expenses Current
Clinical related
Carrying value as of the balance sheet date of obligations incurred through that date and payable for manufacturing of the entity's goods and services. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Manufacturing Related Expenses Current
Manufacturing related
Carrying value as of the balance sheet date of obligations incurred through that date and payable for commercial manufacturing facility related services. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Commercial Manufacturing Facility Related Current
Facilities related
Accrued Professional Fees, Current
Legal and related services
Carrying value as of the balance sheet date of obligations incurred through that date and payable for legal and related services. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Accrued Inventory, Current
Inventory and distribution related
Other Accrued Liabilities, Current
Other accrued expenses
Accrued Liabilities, Current
Total accrued expenses
Schedule of Stock by Class [Table]
Plan Name [Axis]
Plan Name [Domain]
Twenty Eighteen Equity Incentive Plan Member.
The 2018 Plan
The 2018 Plan
Two Thousand Twenty Espp Member.
2020 ESPP
2020 ESPP
ESPP expense
Represents information pertaining to Two Thousand Twenty One Inducement Plan.
2021 Inducement Plan
2021 Inducement Plan
Represents information pertaining to Restricted Stock Units (RSUs) including Performance-Based Restricted Stock Units (PRSUs).
RSUs and PRSUs
RSUs and PRSUs
Represents information relating to performance based restricted stock units.
Performance Based Restricted Stock Unit
Represents the information pertaining to Blank Check.
Blank check
Blank check
Sale of Stock [Axis]
Sale of Stock [Domain]
Private Placement
Private Placement
IPO
IPO
Represents information pertaining to at the market offering program.
At the Market Offering Program
At the Market Offering Program
Represents information pertaining to second sales agreement.
Second Sales Agreement [Member]
Second Sales Agreement
Information pertaining to the a new Open Market Sales Agreement (the "2023 Sales Agreement").
Sales Agreement 2023 [Member]
2023 Sales Agreement
Stock Conversion Description [Axis]
Conversion of Stock, Name [Domain]
Issuance Of Common Stock Upon Conversion Of Preferred Stock
Issuance Of Common Stock Upon Conversion Of Preferred Stock
Statement of Financial Position Location, Activity, Capitalization [Axis]
Statement of Financial Position Location, Activity, Capitalization [Domain]
Inventories [Member]
Inventories
Class of Stock [Line Items]
STOCKHOLDERS' EQUITY
Shares Issued, Price Per Share
Share price (in dollars per share)
The cash inflow from issuance of shares under public offering after deducting underwriting discounts and commissions and estimated offering expenses.
Net Proceeds From Public Offering
Net proceeds from public offering
Maximum amount of shares that can be issued under sale agreement.
Sales Agreement, Authorized Shares To Be Issued, Amount
Maximum amount of shares to be issued
Maximum percentage of gross sales proceeds that will be paid as commission under the sales agreement.
Sales Agreement, Commission, Maximum Percentage Of Gross Sales Proceeds
Maximum percentage of commission
The gross cash inflow from the additional capital contribution to the entity.
Proceeds From Issuance Of Common Stock Gross
Proceeds from the issuance of common stock
Per share or per unit amount of equity securities issued in average price
Weighted Average Price Per Share
Weighted average price
The price per share at which the preferred stock of an entity is converted.
Convertible Price Per Shares
Convertible price per share
Conversion of Stock, Shares Issued
Conversion of stock, shares issued
Conversion of Stock, Shares Converted
Conversion of Stock, shares converted
The total number of shares of common stock into which the convertible preferred stock may be converted, at balance sheet date.
Convertible Preferred Stock Number Of Shares Of Common Stock Available Upon Conversion, Total
Common stock available in conversion, shares
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized
Shares authorized
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Number of shares available
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized
Total unrecognized compensation expense
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition
Unrecognized compensation cost recognition period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted average grant date fair value, options granted
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent
Percentage of purchase price
Allocated Share-based Compensation Expense
Stock-based compensation expense
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Outstanding, Ending balance
Outstanding, Beginning Balance
Outstanding unvested shares
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options
Unrecognized compensation cost
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Nonvested
Aggregate intrinsic value of outstanding non-vested RSUs & PRSUs
Share-Based Payment Arrangement, Amount Capitalized
Stock-based compensation expense
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value
Intrinsic value of options exercised
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Option Indexed to Issuer's Equity, Type [Axis]
Option Indexed to Issuer's Equity, Type [Domain]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
STOCKHOLDERS' EQUITY
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Number of Options
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Outstanding, ending balance
Outstanding, beginning balance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Issued
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period
Expired/Cancelled
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Ending vested and expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Options exercisable
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
Weighted Average Exercise Price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Outstanding, ending balance
Outstanding, beginning balance
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Issued
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Exercised
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price
Expired/Cancelled
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Ending vested and expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Options exercisable
ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosures [Abstract]
Weighted Average Remaining Contractual Life (Years)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Options outstanding, remaining term
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Ending vested and expected to vest, remaining term
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Options exercisable, remaining term
n/a
Aggregate Intrinsic Value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Option at ending balance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Ending vested and expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value
Option exercisable
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Number of Shares
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period
Granted
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period
Vested/Released
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Canceled/Forfeited
Number of fully vested and expected to vest equity-based payment instruments outstanding, excluding stock (or unit) options.
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instrument Other than Options, Vested and Expected to Vest, Outstanding, Number
Ending vested and expected to vest
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Weighted Average Grant Date Fair Value
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Ending Balance
Weighted Average Grant Date Fair Value, Beginning Balance
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Granted
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Vested/Released
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Canceled/forfeited
Per share or unit weighted-average fair value of fully vested and expected to vest equity-based payment instruments outstanding, excluding stock (or unit) options.
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instrument Other than Options, Vested and Expected to Vest, Outstanding, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Ending vested and expected to vest
Cost of Sales [Member]
Cost of Sales
Research and development
Research and development
General and administrative
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost
Total stock-based compensation expense
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Expected term (years)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Reconciliation of Operating Profit (Loss) from Segments to Consolidated [Table]
Segments [Axis]
Segments [Domain]
Represents information pertaining to single reportable segment.
Single Reportable Segment [Member]
Single reportable segment
Segment Reporting, Reconciling Item for Operating Profit (Loss) from Segment to Consolidated [Line Items]
Cost of Goods and Services Sold
Direct cost of goods sold
Amount of acquisition costs related to the cost of goods sold or services rendered.
Acquisition Related Cost of Goods and Services Sold
Acquisition related cost of sales
Royalty Expense
Royalties
Selling and Marketing Expense
Sales and marketing
Segment Reporting, Other Segment Item, Amount
Other segment items
Operating Expenses
Total expenses
N/A.
Segment Reporting, Amount of Increase (Decrease) of Operating Profit (Loss) from Segment to Consolidated [Abstract]
Increase (Decrease) in the amount of net loss
The amount of increase (decrease) in net revenue during the reporting period after deduction of returns, allowances, and discounts.
Increase (Decrease) in Revenue from Contract with Customer, Excluding Assessed Tax
Net sales
The increase (decrease) in the aggregate cost of goods produced and sold and services rendered during the reporting period.
Increase (Decrease) in Cost of Revenue
Total cost of sales
The increase (decrease) in the amount of expense for research and development during the reporting period.
Increase (Decrease) in Research and Development Expense
Research and development
The increase (decrease) in the expenses of managing and administering the affairs of an entity, including affiliates of the reporting entity, which are not directly or indirectly associated with the manufacture, sale or creation of a product or product line.
Increase (Decrease) in General and Administrative Expense
General and administrative
The increase (decrease) in the amount of expenses directly related to the marketing or selling of products or services.
Increase (Decrease) in Selling and Marketing Expense
Sales and marketing
The increase (decrease) in the amount of other expense (income) and loss (gain) calculated as difference between segment revenue and separately disclosed expense category to arrive at segment profit (loss).
Increase (Decrease) in Segment Reporting, Other Segment Item, Amount
Other segment items
The increase (decrease) in the generally recurring costs associated with normal operations except for the portion of these expenses which can be clearly related to production and included in cost of sales or services. Includes selling, general and administrative expense.
Increase (Decrease) in Operating Expenses
Total expenses
The increase (decrease) in the portion of profit or loss for the period, net of income taxes, which is attributable to the parent.
Increase (Decrease) in Net Income (Loss)
Net loss
N/A
Segment Reporting, Percentage of Increase (Decrease) of Operating Profit (Loss) from Segment to Consolidated [Abstract]
Increase (decrease) in the percentage of net loss
Percentage of increase (decrease) in net revenue during the reporting period after deduction of returns, allowances, and discounts.
Percentage of Increase (Decrease) in Revenue from Contract with Customer, Excluding Assessed Tax
Net sales
Percentage of increase (decrease) in the aggregate cost of goods produced and sold and services rendered during the reporting period.
Percentage of Increase (Decrease) in Cost of Revenue
Total cost of sales
Percentage of increase (decrease) in the amount of expense for research and development during the reporting period.
Percentage of Increase (Decrease) in Research and Development Expense
Research and development
Percentage of increase (decrease) in the expenses of managing and administering the affairs of an entity, including affiliates of the reporting entity, which are not directly or indirectly associated with the manufacture, sale or creation of a product or product line.
Percentage of Increase (Decrease) in General and Administrative Expense
General and administrative
Percentage of increase (decrease) in the amount of expenses directly related to the marketing or selling of products or services.
Percentage of Increase (Decrease) in Selling and Marketing Expense
Sales and marketing
Percentage of increase (decrease) in the amount of other expense (income) and loss (gain) calculated as difference between segment revenue and separately disclosed expense category to arrive at segment profit (loss).
Percentage of Increase (Decrease) in Segment Reporting, Other Segment Item, Amount
Other segment items
Percentage of increase (decrease) in the generally recurring costs associated with normal operations except for the portion of these expenses which can be clearly related to production and included in cost of sales or services. Includes selling, general and administrative expense.
Percentage of Increase (Decrease) in Operating Expenses
Total expenses
Percentage of increase (decrease) in the portion of profit or loss for the period, net of income taxes, which is attributable to the parent.
Percentage of Increase (Decrease) in Net Income (Loss)
Net loss
Segment Reporting, Other Segment Item, Composition, Description
Other segment items
Defined Contribution Plan, Cost
Defined contribution plan
Effective Income Tax Rate Reconciliation, Percent
Effective tax rate
Effective tax rates
Amount of loss before provision of income taxes of U.S. losses.
Loss Before Provision Of Income Taxes Of U.S. Losses
Loss before provision of income taxes of U.S. losses
Amount of loss before provision of income taxes of foreign losses.
Loss Before Provision Of Income Taxes Of Foreign Losses
Loss before provision of income taxes of foreign losses
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Federal statutory tax rate
Deferred Tax Assets, Net [Abstract]
Deferred income tax asset:
Deferred Tax Assets, Operating Loss Carryforwards
Net operating loss carry forwards
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost
Stock-based compensation
Deferred Tax Assets, Tax Credit Carryforwards
Tax credit carryforwards
Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from lease liabilities.
Deferred Tax Assets, Lease Liabilities
Lease liabilities
Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from research and development costs.
Deferred Tax Assets, Capitalized Research and Development
Capitalized R&D
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals
Reserves and accruals
Deferred Tax Assets, Gross
Deferred tax assets before valuation allowance
Deferred Tax Assets, Valuation Allowance
Less: valuation allowance
Deferred Tax Assets, Net of Valuation Allowance
Net deferred income tax assets
Deferred Tax Liabilities, Gross [Abstract]
Deferred tax liabilities:
Amount of deferred tax liability attributable to taxable temporary differences from right of use assets.
Deferred Tax Liabilities, Right Of Use Assets
Right-of-use assets
Amount of deferred tax liability attributable to taxable temporary differences depreciation and amortization.
Deferred Tax Liabilities, Depreciation And Amortization
Depreciation and amortization
Deferred Tax Liabilities, Net
Net deferred tax assets (liabilities)
Effective Income Tax Rate Reconciliation, Tax Credit, Percent
Orphan drug and research credits
Effective Income Tax Rate Reconciliation, Other Adjustments, Percent
Permanent and other differences
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Stock-based compensation
Effective Income Tax Rate Reconciliation, Tax Settlement, State and Local, Percent
State tax, net of federal benefit
Represents the sum of Federal Statutory tax rate and State tax net of federal benefit.
Effective Income Tax Rate Reconciliation, Expected Rate Total 1
Effective Income Tax Rate Reconciliation Expected Rate Total
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Valuation allowance
Income Tax Contingency [Table]
Income Tax Authority [Axis]
Income Tax Authority [Domain]
Federal income tax
State income tax
Income Tax Contingency [Line Items]
Operating Loss Carryforwards
Net operating loss carryforwards (NOLs)
Operating Loss Carry forwards Having Definite Expire life Value.
Operating Loss Carry forwards Having Definite Expire life Value
Operating loss carryovers definite to be expired
Operating Loss Carry forwards Having Indefinite Expire life Value.
Operating Loss Carry forwards Having Indefinite Expire life Value
Operating loss carryovers indefinite
Tax Credit Carryforward, Amount
Tax credit carryforwards
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Change in valuation allowance
Unrecognized Tax Benefits
Unrecognized benefit - end of period
Unrecognized benefit - beginning of period
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Gross decreases - prior period tax positions
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Gross increase current period tax positions
Cooperative Research and Development Agreement
WuXi Apptech, Inc - Manufacturing and Services Agreement
Represents information pertaining to Cellectis S.A.
Cellectis S.A
Represents the information pertaining to Novartis pharma AG and Related Entities License Agreement.
Novartis Pharma AG And Related Entities License Agreement [Member]
Novartis Pharma AG and Related Entities - License Agreement
Type of Arrangement and Non-arrangement Transactions [Axis]
Arrangements and Non-arrangement Transactions [Domain]
Represent the information pertaining to sponsored research agreement.
Sponsored research agreement
Represents the information pertaining to first wuxi manufacturing and services agreement.
First WuXi Manufacturing and Services Agreement
Represents the information pertaining to second wuxi manufacturing and services agreement.
Second WuXi Manufacturing and Services Agreement
This member stands for Patent License Agreement Related to the Development and Manufacture of TIL Therapies.
Patent License Agreement Related to the Development and Manufacture of TIL Therapies [Member]
Patent license agreement related to the development and manufacture of TIL therapies
This member stands for Second Amended and Restated Patent License Agreement.
Second Amended and Restated Patent License Agreement [Member]
Second Amended and Restated Patent License Agreement
Represents the information pertaining to patent license agreement related to the company sponsored Phase 2 Clinical Study in Melanoma.
Patent License Agreement, Related to Phase 2 Clinical Study in Melanoma [Member]
Phase 2 Clinical Study in Melanoma
Represents the information pertaining to patent license agreement related to the approval of Amtagvi.
Patent License Agreement, Related to approval of Amtagvi [Member]
Patent License Agreement, Related to approval of Amtagvi
Represents the information pertaining to patent license agreement related to the approval of the first commercial sale of Amtagvi.
Patent License Agreement, Related to approval of the first commercial sale of Amtagvi [Member]
Patent License Agreement, Related to approval of the first commercial sale of Amtagvi
Category of Item Purchased [Axis]
Long-term Purchase Commitment, Category of Item Purchased [Domain]
Strategic Alliance Agreement
Scenario [Axis]
Scenario, Unspecified [Domain]
Represents the member information pertaining to through the end of 2024.
Through the End of 2024 [Member]
Through the end of 2024
Represents the member information pertaining to commencing in 2025 and end of agreement term.
Commencing in 2025 and End of Agreement Term [Member]
Commencing in 2025 and end of agreement term
It represents the term of agreement.
Agreement Term
Agreement term
Represents the required quarterly payments under research and development agreement.
Research and Development Agreement, Required Quarterly Payment
Quarterly payment for research and development
Amount required to be remitted under the collaborative arrangement .
Collaborative Arrangement, Amount Required To Be Remitted
Amount of collaborative arrangement required to be remitted
Period within which the company is required to be remit the specified amount under the collaborative arrangement.
Collaborative Arrangement, Period To Remit Required Amount
Period of collaborative arrangement required to be remitted
The required notification period before the party may terminate the agreement.
Notification Period To Terminate Agreement
Notification period to terminate agreement
The amortization of milestone payments.
License Agreement, Amortization of Milestone Payment
License agreement
Research and Development Arrangement, Contract to Perform for Others, Costs Incurred, Gross
Research and development arrangement, contract to perform for others, costs incurred, gross
The number of suites under the agreement.
Number Of Suites Under The Agreement
Number of historical asset purchase agreement.
Number of Historical Asset Purchase Agreement
Number of historical asset purchase agreement.
Number of historical master cell bank license and working cell bank transfer agreement.
Number of Historical Master Cell Bank License and Working Cell Bank Transfer Agreement
Number of historical master cell bank license and working cell bank transfer agreement
Number of historical license agreement.
Number of Historical License Agreement
Number of historical license agreement
The amount of milestone payments payable under the license agreement.
License Agreement Milestone Payments Payable
Amount of milestone payments payable under the license agreement
The amount of milestone payment made during the period under the license agreement.
License Agreement, Milestone Payment
Amount of milestone payment made during the period under the license agreement
The percent of milestone payments reimbursable by deduction from deferred consideration.
License Agreement, Percent of Milestone Payments Reimbursable
Percent of milestone payments reimbursable
Represents information pertaining to manufacturing and supply agreement from Clinigen with Boehringer Ingelheim Biopharmaceuticals GmbH.
Manufacturing and Supply Agreement With Boehringer Ingelheim Biopharmaceuticals GmbH [Member]
Manufacturing and Supply Agreement With Boehringer Ingelheim Biopharmaceuticals GmbH
Represents the automatic renewal term of supply agreement.
Supply Agreement, Automatic Renewal Term
Renewal term of agreement
Purchase Obligation, to be Paid, Year One
Years ending December 31, 2025
Purchase Obligation, to be Paid, Year Two
Years ending December 31, 2026
Purchase Obligation, to be Paid, Year Three
Years ending December 31, 2027
Represents the member information pertaining to sublease agreement ("the New Headquarters Lease").
Sub Lease Agreement [Member]
Sub Lease Agreement
Furniture and equipment
This member stands for Philadelphia, Pennsylvania.
Philadelphia, Pennsylvania
Philadelphia, Pennsylvania
Area of Land
Area of land
Lessee, Operating Lease, Term of Contract
Term of contract in years
Number of options to extend the lease.
Lessee, Operating Lease, Number of Options to Extend Lease
Number of options to extend the lease
Lessee, Operating Lease, Option to Extend
Option to extend
Lessee, Operating Lease, Existence of Option to Extend [true false]
Existence of option to extend lease
Lessee, Operating Lease, Renewal Term
Renewal term in years
Percentage of increase in monthly base rent of lease from its current amount under extension option.
Lessee, Operating Lease, Extension, Percentage of Increase in Monthly Base Rent
Percentage of increase in monthly base rent upon extension
The amount of monthly base rent under operating lease of lessee.
Lessee, Operating Lease, Monthly Base Rent
Monthly base rent
Operating Lease, Liability
Operating lease liability
Total operating lease liabilities
Operating lease liabilities
Area of land surrendered.
Area of Land Surrendered
Area of land surrendered
The amount of cash outflow associated with the payment of early termination.
Lessee, Operating Lease, Amount of Early Lease Termination Fees Paid
Early termination payment
The amount of cash outflow associated with the payment of related brokerage fees.
Lessee, Operating Lease, Amount of Brokerage Fee Paid
Brokerage fees paid
Amount of derecognition of right of use assets at the time of termination or modification of lease agreement.
Derecognition Of Operating Lease Right-Of-Use Assets
Derecognition of operating lease right-of-use assets
mount of derecognition of lease liabilities at the time of termination or modification of lease agreement.
Derecognition Of Operating Lease Liabilities
Derecognition of operating lease liabilities
Payments for Tenant Improvements
Tenant improvement allowance
Amount of reimbursement received from tenant improvement allowance.
Tenant Improvement Allowance, Reimbursement Received
Tenant improvement allowance reimbursed
Operating Lease Liability [Abstract]
Operating lease liabilities
Operating Lease, Cost
Operating lease cost
Variable Lease, Cost
Variable lease cost
Short-term Lease, Cost
Short-term lease cost
Lease, Cost
Total lease cost
Operating Lease, Payments
Cash paid for amounts included in the measurement of lease liabilities included in cash flows from operations
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Right-of-use assets obtained from entering new leases
Amount of increase (decrease) in right-of-use assets from lease modifications.
Increase /(Decrease) In Right-Of-Use Assets From Lease Modifications
Increase in right-of-use assets from lease modifications
Operating Lease, Weighted Average Remaining Lease Term
Weighted-average remaining lease terms (years)
Operating Lease, Weighted Average Discount Rate, Percent
Weighted-average discount rates
Facility leases
CMO embedded leases
Operating Leases, Future Minimum Payments, Due in Two Years
2025
Lessee, Operating Lease, Liability, Payments, Due Year Two
2026
Lessee, Operating Lease, Liability, Payments, Due Year Three
2027
Lessee, Operating Lease, Liability, Payments, Due Year Four
2028
Lessee, Operating Lease, Liability, Payments, Due Year Five
2028
Lessee, Operating Lease, Liability, Payments, Due after Year Five
Thereafter
Lessee, Operating Lease, Liability, Payments, Due
Total lease payments
Operating Lease Present Value Adjustments
Less: Present value adjustment
Litigation Case [Axis]
Litigation Case [Domain]
Information pertaining to lawsuit brought by Solomon Capital LLC et al.
Solomon Capital LLC Litigation
Proceeds from Other Debt
Proceeds from lawsuit filed
Debt Instrument, Face Amount
Face amount
Debt Instrument, Convertible, Number of Equity Instruments
Debt instrument, convertible, number of equity instruments
Stockholders' Equity Note, Stock Split, Conversion Ratio
Reverse split ratio
Loss Contingency, Estimate of Possible Loss
Estimate of possible loss
Loss Contingency, Damages Sought, Value
Damages claimed
The amount of equity claim.
Equity Claim
Equity claim
The number of shares allegedly issued in breach of fiduciary duty, during the period.
Shares Issued in Breach of Fiduciary Duty
Public offering