<?xml version="1.0" encoding="utf-8"?>
<!--XBRL document created with Toppan Merrill Bridge  10.9.0.3 -->
<!--Based on XBRL 2.1-->
<!--Created on: 2/27/2025 6:01:05 PM-->
<!--Modified on: 2/27/2025 6:01:05 PM-->
<xsd:schema xmlns:exch="http://xbrl.sec.gov/exch/2024" xmlns:us-types="http://fasb.org/us-types/2024" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:srt="http://fasb.org/srt/2024" xmlns:stpr="http://xbrl.sec.gov/stpr/2024" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xl="http://www.xbrl.org/2003/XLink" xmlns:country="http://xbrl.sec.gov/country/2024" xmlns:naics="http://xbrl.sec.gov/naics/2024" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:sic="http://xbrl.sec.gov/sic/2024" xmlns:us-gaap="http://fasb.org/us-gaap/2024" xmlns:currency="http://xbrl.sec.gov/currency/2024" targetNamespace="http://lbio.com/20241231" elementFormDefault="qualified" xmlns:srt-types="http://fasb.org/srt-types/2024" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2022-03-31" xmlns:iova="http://lbio.com/20241231" xmlns:enum2="http://xbrl.org/2020/extensible-enumerations-2.0" xmlns:deprecated="http://www.xbrl.org/2009/role/deprecated" xmlns:us-roles="http://fasb.org/us-roles/2024" xmlns:ref="http://www.xbrl.org/2006/ref" xmlns:srt-roles="http://fasb.org/srt-roles/2024" xmlns:utr="http://www.xbrl.org/2009/utr" xmlns:net="http://www.xbrl.org/2009/role/net" xmlns:dei="http://xbrl.sec.gov/dei/2024" xmlns:negated="http://www.xbrl.org/2009/role/negated" xmlns:attributeFormDefault="unqualified" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:dtr="http://www.xbrl.org/2009/dtr" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:us-gaap-ebp="http://fasb.org/us-gaap-ebp/2024" xmlns:cyd-af-sub="http://xbrl.sec.gov/cyd-af-sub/2024" xmlns:ecd="http://xbrl.sec.gov/ecd/2024" xmlns:ecd-sub="http://xbrl.sec.gov/ecd-sub/2024" xmlns:cyd="http://xbrl.sec.gov/cyd/2024">
  <xsd:annotation>
    <xsd:appinfo>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStandardAndCustomAxisDomainDefaults" id="DisclosureStandardAndCustomAxisDomainDefaults">
        <link:definition>99900 - Disclosure - Standard And Custom Axis Domain Defaults</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/StatementConsolidatedBalanceSheets" id="StatementConsolidatedBalanceSheets">
        <link:definition>995200100 - Statement - Consolidated Balance Sheets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/StatementConsolidatedStatementsOfOperations" id="StatementConsolidatedStatementsOfOperations">
        <link:definition>995200200 - Statement - Consolidated Statements of Operations</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/StatementConsolidatedStatementsOfComprehensiveLoss" id="StatementConsolidatedStatementsOfComprehensiveLoss">
        <link:definition>995200300 - Statement - Consolidated Statements of Comprehensive Loss</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/StatementConsolidatedStatementsOfCashFlows" id="StatementConsolidatedStatementsOfCashFlows">
        <link:definition>995200500 - Statement - Consolidated Statements of Cash Flows</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPracticesCashCashEquivalentsAndRestrictedCashDetails" id="DisclosureSummaryOfSignificantAccountingPracticesCashCashEquivalentsAndRestrictedCashDetails">
        <link:definition>99940201 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES - Cash, Cash equivalents and Restricted Cash (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureCashEquivalentsAndInvestmentsAvailableForSaleDebtSecuritiesDetails" id="DisclosureCashEquivalentsAndInvestmentsAvailableForSaleDebtSecuritiesDetails">
        <link:definition>99940302 - Disclosure - CASH EQUIVALENTS AND INVESTMENTS - Available for sale debt securities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIntangibleAssetsNetDetails" id="DisclosureIntangibleAssetsNetDetails">
        <link:definition>99940501 - Disclosure - INTANGIBLE ASSETS, NET (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureInventoryDetails" id="DisclosureInventoryDetails">
        <link:definition>99940601 - Disclosure - INVENTORY (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureRevenueGtnAdjustmentsDetails" id="DisclosureRevenueGtnAdjustmentsDetails">
        <link:definition>99940702 - Disclosure - REVENUE - GTN Adjustments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosurePropertyAndEquipmentNetDetails" id="DisclosurePropertyAndEquipmentNetDetails">
        <link:definition>99940801 - Disclosure - PROPERTY AND EQUIPMENT, NET - (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureAccruedExpensesDetails" id="DisclosureAccruedExpensesDetails">
        <link:definition>99940901 - Disclosure - ACCRUED EXPENSES (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIncomeTaxesNetDeferredTaxAssetsAndLiabilitiesDetails" id="DisclosureIncomeTaxesNetDeferredTaxAssetsAndLiabilitiesDetails">
        <link:definition>99941302 - Disclosure - INCOME TAXES - Net deferred tax assets and liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIncomeTaxesReconciliationOfEffectiveIncomeTaxRateDetails" id="DisclosureIncomeTaxesReconciliationOfEffectiveIncomeTaxRateDetails">
        <link:definition>99941303 - Disclosure - INCOME TAXES - Reconciliation of the effective income tax rate (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureMaturitiesOfCompanySOperatingLeaseLiabilitiesDetailsCalc2" id="DisclosureMaturitiesOfCompanySOperatingLeaseLiabilitiesDetailsCalc2">
        <link:definition>41404 - Disclosure - Maturities of the Company's operating lease liabilities (Details) (Calc 2)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLeasesRightOfUseAssetAndLeaseLiabilitiesDetails" id="DisclosureLeasesRightOfUseAssetAndLeaseLiabilitiesDetails">
        <link:definition>99941502 - Disclosure - LEASES - Right-of-use asset and lease liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLeasesComponentsOfLeaseExpensesDetails" id="DisclosureLeasesComponentsOfLeaseExpensesDetails">
        <link:definition>99941503 - Disclosure - LEASES - Components of lease expenses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLeasesMaturitiesOfCompanySOperatingLeaseLiabilitiesDetails" id="DisclosureLeasesMaturitiesOfCompanySOperatingLeaseLiabilitiesDetails">
        <link:definition>99941504 - Disclosure - LEASES - Maturities of the Company's operating lease liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DocumentDocumentAndEntityInformation" id="DocumentDocumentAndEntityInformation">
        <link:definition>995200090 - Document - Document And Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/StatementConsolidatedBalanceSheetsParenthetical" id="StatementConsolidatedBalanceSheetsParenthetical">
        <link:definition>995200105 - Statement - Consolidated Balance Sheets (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/StatementConsolidatedStatementsOfStockholdersEquity" id="StatementConsolidatedStatementsOfStockholdersEquity">
        <link:definition>995200400 - Statement - Consolidated Statements of Stockholders' Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureGeneralOrganizationBusinessAndLiquidityDetails" id="DisclosureGeneralOrganizationBusinessAndLiquidityDetails">
        <link:definition>99940101 - Disclosure - GENERAL ORGANIZATION, BUSINESS AND LIQUIDITY (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPracticesUsefulLivesImpairmentDetails" id="DisclosureSummaryOfSignificantAccountingPracticesUsefulLivesImpairmentDetails">
        <link:definition>99940202 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES - Useful lives, impairment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPracticesNetLossPerShareDetails" id="DisclosureSummaryOfSignificantAccountingPracticesNetLossPerShareDetails">
        <link:definition>99940203 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES - Net Loss per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPracticesIncomeTaxesSegmentReportingDetails" id="DisclosureSummaryOfSignificantAccountingPracticesIncomeTaxesSegmentReportingDetails">
        <link:definition>99940204 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES - Income taxes &amp; Segment Reporting (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureCashEquivalentsAndInvestmentsCostAndFairValueDetails" id="DisclosureCashEquivalentsAndInvestmentsCostAndFairValueDetails">
        <link:definition>99940301 - Disclosure - CASH EQUIVALENTS AND INVESTMENTS - Cost and fair value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureCashEquivalentsAndInvestmentsNarrativeDetails" id="DisclosureCashEquivalentsAndInvestmentsNarrativeDetails">
        <link:definition>99940303 - Disclosure - CASH EQUIVALENTS AND INVESTMENTS - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureCashEquivalentsAndInvestmentsFairValueOfCompanySFinancialAssetsDetails" id="DisclosureCashEquivalentsAndInvestmentsFairValueOfCompanySFinancialAssetsDetails">
        <link:definition>99940304 - Disclosure - CASH EQUIVALENTS AND INVESTMENTS - Fair value of company's financial assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureProleukinAcquisitionNarrativeDetails" id="DisclosureProleukinAcquisitionNarrativeDetails">
        <link:definition>99940401 - Disclosure - PROLEUKIN ACQUISITION - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureProleukinAcquisitionCashConsiderationAndAllocatedFairValueOfAssetsAcquiredAndLiabilityAssumedDetails" id="DisclosureProleukinAcquisitionCashConsiderationAndAllocatedFairValueOfAssetsAcquiredAndLiabilityAssumedDetails">
        <link:definition>99940402 - Disclosure - PROLEUKIN ACQUISITION - Cash consideration and allocated fair value of assets acquired and liability assumed (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureProleukinAcquisitionAdditionalInformationDetails" id="DisclosureProleukinAcquisitionAdditionalInformationDetails">
        <link:definition>99940403 - Disclosure - PROLEUKIN ACQUISITION - Additional information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureRevenueDetails" id="DisclosureRevenueDetails">
        <link:definition>99940701 - Disclosure - REVENUE (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureRevenueConsolidatedNetProductRevenueByGeographicAreaDetails" id="DisclosureRevenueConsolidatedNetProductRevenueByGeographicAreaDetails">
        <link:definition>99940703 - Disclosure - REVENUE - Consolidated net product revenue by geographic area (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureRevenueConcentrationDetails" id="DisclosureRevenueConcentrationDetails">
        <link:definition>99940704 - Disclosure - REVENUE - Concentration (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosurePropertyAndEquipmentNetOtherInformationDetails" id="DisclosurePropertyAndEquipmentNetOtherInformationDetails">
        <link:definition>99940802 - Disclosure - PROPERTY AND EQUIPMENT, NET - Other information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockholdersEquityDetails" id="DisclosureStockholdersEquityDetails">
        <link:definition>99941001 - Disclosure - STOCKHOLDERS' EQUITY (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockholdersEquityStockOptionsDetails" id="DisclosureStockholdersEquityStockOptionsDetails">
        <link:definition>99941002 - Disclosure - STOCKHOLDERS' EQUITY - Stock Options (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockholdersEquityRestrictedStockUnitsAndPerformanceRestrictedStockUnitsDetails" id="DisclosureStockholdersEquityRestrictedStockUnitsAndPerformanceRestrictedStockUnitsDetails">
        <link:definition>99941003 - Disclosure - STOCKHOLDERS' EQUITY - Restricted Stock Units and Performance Restricted Stock Units (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockholdersEquityStockBasedExpenseDetails" id="DisclosureStockholdersEquityStockBasedExpenseDetails">
        <link:definition>99941004 - Disclosure - STOCKHOLDERS' EQUITY - Stock based expense (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockholdersEquityStockBasedCompensationByInstrumentDetails" id="DisclosureStockholdersEquityStockBasedCompensationByInstrumentDetails">
        <link:definition>99941005 - Disclosure - STOCKHOLDERS' EQUITY - Stock-based compensation by instrument (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockholdersEquityAssumptionsDetails" id="DisclosureStockholdersEquityAssumptionsDetails">
        <link:definition>99941006 - Disclosure - STOCKHOLDERS' EQUITY - Assumptions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSegmentInformationDetails" id="DisclosureSegmentInformationDetails">
        <link:definition>99941101 - Disclosure - SEGMENT INFORMATION (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureEmployeeBenefitPlanDetails" id="DisclosureEmployeeBenefitPlanDetails">
        <link:definition>99941201 - Disclosure - EMPLOYEE BENEFIT PLAN (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIncomeTaxesOtherInformationDetails" id="DisclosureIncomeTaxesOtherInformationDetails">
        <link:definition>99941304 - Disclosure - INCOME TAXES - Other information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIncomeTaxesUnrecognizedBenefitsDetails" id="DisclosureIncomeTaxesUnrecognizedBenefitsDetails">
        <link:definition>99941305 - Disclosure - INCOME TAXES - Unrecognized benefits (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLicensesAndAgreementsDetails" id="DisclosureLicensesAndAgreementsDetails">
        <link:definition>99941401 - Disclosure - LICENSES AND AGREEMENTS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLicensesAndAgreementsEstimatedPurchaseObligationsDetails" id="DisclosureLicensesAndAgreementsEstimatedPurchaseObligationsDetails">
        <link:definition>99941402 - Disclosure - LICENSES AND AGREEMENTS - Estimated purchase obligations (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLeasesAdditionalInformationDetails" id="DisclosureLeasesAdditionalInformationDetails">
        <link:definition>99941501 - Disclosure - LEASES - Additional information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLegalProceedingsDetails" id="DisclosureLegalProceedingsDetails">
        <link:definition>99941601 - Disclosure - LEGAL PROCEEDINGS (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureGeneralOrganizationBusinessAndLiquidity" id="DisclosureGeneralOrganizationBusinessAndLiquidity">
        <link:definition>995210101 - Disclosure - GENERAL ORGANIZATION, BUSINESS AND LIQUIDITY</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPractices" id="DisclosureSummaryOfSignificantAccountingPractices">
        <link:definition>995210201 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureCashEquivalentsAndInvestments" id="DisclosureCashEquivalentsAndInvestments">
        <link:definition>995210301 - Disclosure - CASH EQUIVALENTS AND INVESTMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureProleukinAcquisition" id="DisclosureProleukinAcquisition">
        <link:definition>995210401 - Disclosure - PROLEUKIN ACQUISITION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIntangibleAssetsNet" id="DisclosureIntangibleAssetsNet">
        <link:definition>995210501 - Disclosure - INTANGIBLE ASSETS, NET</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureInventory" id="DisclosureInventory">
        <link:definition>995210601 - Disclosure - INVENTORY</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureRevenue" id="DisclosureRevenue">
        <link:definition>995210701 - Disclosure - REVENUE</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosurePropertyAndEquipmentNet" id="DisclosurePropertyAndEquipmentNet">
        <link:definition>995210801 - Disclosure - PROPERTY AND EQUIPMENT, NET</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureAccruedExpenses" id="DisclosureAccruedExpenses">
        <link:definition>995210901 - Disclosure - ACCRUED EXPENSES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockholdersEquity" id="DisclosureStockholdersEquity">
        <link:definition>995211001 - Disclosure - STOCKHOLDERS' EQUITY</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSegmentInformation" id="DisclosureSegmentInformation">
        <link:definition>995211101 - Disclosure - SEGMENT INFORMATION</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureEmployeeBenefitPlan" id="DisclosureEmployeeBenefitPlan">
        <link:definition>995211201 - Disclosure - EMPLOYEE BENEFIT PLAN</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIncomeTaxes" id="DisclosureIncomeTaxes">
        <link:definition>995211301 - Disclosure - INCOME TAXES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLicensesAndAgreements" id="DisclosureLicensesAndAgreements">
        <link:definition>995211401 - Disclosure - LICENSES AND AGREEMENTS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLeases" id="DisclosureLeases">
        <link:definition>995211501 - Disclosure - LEASES</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLegalProceedings" id="DisclosureLegalProceedings">
        <link:definition>995211601 - Disclosure - LEGAL PROCEEDINGS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPracticesPolicies" id="DisclosureSummaryOfSignificantAccountingPracticesPolicies">
        <link:definition>99920202 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSummaryOfSignificantAccountingPoliciesTables" id="DisclosureSummaryOfSignificantAccountingPoliciesTables">
        <link:definition>99930203 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureCashEquivalentsAndInvestmentsTables" id="DisclosureCashEquivalentsAndInvestmentsTables">
        <link:definition>99930303 - Disclosure - CASH EQUIVALENTS AND INVESTMENTS (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureProleukinAcquisitionTables" id="DisclosureProleukinAcquisitionTables">
        <link:definition>99930403 - Disclosure - PROLEUKIN ACQUISITION (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIntangibleAssetsNetTables" id="DisclosureIntangibleAssetsNetTables">
        <link:definition>99930503 - Disclosure - INTANGIBLE ASSETS, NET (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureInventoryTables" id="DisclosureInventoryTables">
        <link:definition>99930603 - Disclosure - INVENTORY (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureRevenueTables" id="DisclosureRevenueTables">
        <link:definition>99930703 - Disclosure - REVENUE (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosurePropertyAndEquipmentNetTables" id="DisclosurePropertyAndEquipmentNetTables">
        <link:definition>99930803 - Disclosure - PROPERTY AND EQUIPMENT, NET (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureAccruedExpensesTables" id="DisclosureAccruedExpensesTables">
        <link:definition>99930903 - Disclosure - ACCRUED EXPENSES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureStockholdersEquityTables" id="DisclosureStockholdersEquityTables">
        <link:definition>99931003 - Disclosure - STOCKHOLDERS' EQUITY (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureSegmentInformationTables" id="DisclosureSegmentInformationTables">
        <link:definition>99931103 - Disclosure - SEGMENT INFORMATION (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIncomeTaxesTables" id="DisclosureIncomeTaxesTables">
        <link:definition>99931303 - Disclosure - INCOME TAXES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureLeasesTables" id="DisclosureLeasesTables">
        <link:definition>99931503 - Disclosure - LEASES (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://lbio.com/role/DisclosureIncomeTaxesDetails" id="DisclosureIncomeTaxesDetails">
        <link:definition>99941301 - Disclosure - INCOME TAXES (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:linkbaseRef xlink:type="simple" xlink:href="iova-20241231_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="iova-20241231_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="iova-20241231_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
      <link:linkbaseRef xlink:type="simple" xlink:href="iova-20241231_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:import namespace="https://xbrl.org/2023/calculation-1.1" schemaLocation="https://www.xbrl.org/2023/calculation-1.1.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/ecd/2024" schemaLocation="https://xbrl.sec.gov/ecd/2024/ecd-2024.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/dei/2024" schemaLocation="https://xbrl.sec.gov/dei/2024/dei-2024.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <xsd:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/dtr/type/2022-03-31" schemaLocation="https://www.xbrl.org/dtr/type/2022-03-31/types.xsd" />
  <xsd:import namespace="http://fasb.org/us-roles/2024" schemaLocation="https://xbrl.fasb.org/us-gaap/2024/elts/us-roles-2024.xsd" />
  <xsd:import namespace="http://fasb.org/us-gaap/2024" schemaLocation="https://xbrl.fasb.org/us-gaap/2024/elts/us-gaap-2024.xsd" />
  <xsd:import namespace="http://fasb.org/srt/2024" schemaLocation="https://xbrl.fasb.org/srt/2024/elts/srt-2024.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/country/2024" schemaLocation="https://xbrl.sec.gov/country/2024/country-2024.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/ecd-sub/2024" schemaLocation="https://xbrl.sec.gov/ecd/2024/ecd-sub-2024.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/cyd/2024" schemaLocation="https://xbrl.sec.gov/cyd/2024/cyd-2024.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/cyd-af-sub/2024" schemaLocation="https://xbrl.sec.gov/cyd/2024/cyd-af-sub-2024.xsd" />
  <xsd:element name="LicensesAndAgreementsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_LicensesAndAgreementsAbstract" substitutionGroup="xbrli:item" />
  <xsd:element name="LicensesAndAgreementsDisclosureTextBlock" type="dtr-types:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="iova_LicensesAndAgreementsDisclosureTextBlock" substitutionGroup="xbrli:item" />
  <xsd:element name="ClinicalRelatedExpensesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="iova_ClinicalRelatedExpensesCurrent" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element id="iova_ManufacturingRelatedExpensesCurrent" name="ManufacturingRelatedExpensesCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element name="SharebasedcompensationarrangementbysharebasedpaymentawardoptionsadditionaldisclosuresAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_SharebasedcompensationarrangementbysharebasedpaymentawardoptionsadditionaldisclosuresAbstract" substitutionGroup="xbrli:item" />
  <xsd:element name="IssuanceOfCommonStockUponConversionOfPreferredStockMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_IssuanceOfCommonStockUponConversionOfPreferredStockMember" substitutionGroup="xbrli:item" />
  <xsd:element id="iova_ConvertiblePricePerShares" name="ConvertiblePricePerShares" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="iova_ProceedsFromIssuanceOfCommonStockGross" name="ProceedsFromIssuanceOfCommonStockGross" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="iova_TwentyEighteenEquityIncentivePlanMember" name="TwentyEighteenEquityIncentivePlanMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element name="DeferredTaxLiabilitiesDepreciationAndAmortization" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="iova_DeferredTaxLiabilitiesDepreciationAndAmortization" substitutionGroup="xbrli:item" xbrli:balance="credit" />
  <xsd:element name="OperatingLossCarryForwardsHavingDefiniteExpireLifeValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="iova_OperatingLossCarryForwardsHavingDefiniteExpireLifeValue" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="OperatingLossCarryForwardsHavingIndefiniteExpireLifeValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="iova_OperatingLossCarryForwardsHavingIndefiniteExpireLifeValue" substitutionGroup="xbrli:item" xbrli:balance="debit" />
  <xsd:element name="CooperativeResearchAndDevelopmentAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_CooperativeResearchAndDevelopmentAgreementMember" substitutionGroup="xbrli:item" />
  <xsd:element name="WuxiApptechIncManufacturingAndServicesAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_WuxiApptechIncManufacturingAndServicesAgreementMember" substitutionGroup="xbrli:item" />
  <xsd:element name="StrategicAllianceAgreementMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_StrategicAllianceAgreementMember" substitutionGroup="xbrli:item" />
  <xsd:element id="iova_AgreementTerm" name="AgreementTerm" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element name="FacilityLeasesMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_FacilityLeasesMember" substitutionGroup="xbrli:item" />
  <xsd:element name="OfficeSpaceMember" type="dtr-types:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="iova_OfficeSpaceMember" substitutionGroup="xbrli:item" />
  <xsd:element id="iova_ScheduleOfUsefulLivesOfPropertyPlantAndEquipmentTableTextBlock" name="ScheduleOfUsefulLivesOfPropertyPlantAndEquipmentTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="iova_NumberOfFinancialInstitutions" name="NumberOfFinancialInstitutions" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="iova_NotificationPeriodToTerminateAgreement" name="NotificationPeriodToTerminateAgreement" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="iova_NumberOfSuitesUnderAgreement" name="NumberOfSuitesUnderAgreement" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="iova_SolomonCapitalLlcLitigationMember" name="SolomonCapitalLlcLitigationMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_ConvertiblePreferredStockNumberOfSharesOfCommonStockAvailableUponConversionTotal" name="ConvertiblePreferredStockNumberOfSharesOfCommonStockAvailableUponConversionTotal" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="iova_SupplementalBalanceSheetInformationRelatedToLeasesTableTextBlock" name="SupplementalBalanceSheetInformationRelatedToLeasesTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="iova_SharesIssuedPlanAxis" name="SharesIssuedPlanAxis" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_SharesIssuedPlanDomain" name="SharesIssuedPlanDomain" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_CmoEmbeddedLeasesMember" name="CmoEmbeddedLeasesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_BlankCheckMember" name="BlankCheckMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_ScheduleOfCashAndCashEquivalentsAndRestrictedCashTableTextBlock" name="ScheduleOfCashAndCashEquivalentsAndRestrictedCashTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="iova_AggregateIntrinsicValueAbstract" name="AggregateIntrinsicValueAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_AccountingPoliciesTable" name="AccountingPoliciesTable" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_AccountingPoliciesLineItems" name="AccountingPoliciesLineItems" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_RestrictedCashPolicyTextBlock" name="RestrictedCashPolicyTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="iova_DeferredTaxAssetsLeaseLiabilities" name="DeferredTaxAssetsLeaseLiabilities" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="iova_EffectiveIncomeTaxRateReconciliationExpectedRateTotal1" name="EffectiveIncomeTaxRateReconciliationExpectedRateTotal1" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="iova_CommercialManufacturingFacilityRelatedCurrent" name="CommercialManufacturingFacilityRelatedCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="iova_CellectisS.aMember" name="CellectisS.aMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_IncreaseDecreaseInRightOfUseAssetsFromLeaseModifications" name="IncreaseDecreaseInRightOfUseAssetsFromLeaseModifications" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="iova_EquityClaim" name="EquityClaim" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="iova_TwoThousandTwentyEsppMember" name="TwoThousandTwentyEsppMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_SanCarlosCaliforniaMember" name="SanCarlosCaliforniaMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_PhiladelphiaPennsylvaniaMember" name="PhiladelphiaPennsylvaniaMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_NewHeadquartersLeaseMember" name="NewHeadquartersLeaseMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_EmployeeStockPurchasePlanMember" name="EmployeeStockPurchasePlanMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_AcquisitionsOfPropertyAndEquipmentIncludedInAccountsPayableAndAccruedExpense" name="AcquisitionsOfPropertyAndEquipmentIncludedInAccountsPayableAndAccruedExpense" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="iova_AtMarketOfferingProgramMember" name="AtMarketOfferingProgramMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_SalesAgreementAuthorizedSharesToBeIssuedAmount" name="SalesAgreementAuthorizedSharesToBeIssuedAmount" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="iova_SalesAgreementCommissionMaximumPercentageOfGrossSalesProceeds" name="SalesAgreementCommissionMaximumPercentageOfGrossSalesProceeds" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="iova_WeightedAveragePricePerShare" name="WeightedAveragePricePerShare" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="iova_TwoThousandTwentyOneInducementPlanMember" name="TwoThousandTwentyOneInducementPlanMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_CashCashEquivalentsAndShortTermInvestmentsAndRestrictedCashTotal" name="CashCashEquivalentsAndShortTermInvestmentsAndRestrictedCashTotal" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="iova_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiabilityFromLeaseModifications" name="RightOfUseAssetObtainedInExchangeForOperatingLeaseLiabilityFromLeaseModifications" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="iova_Rightofuseassetobtainedinexchangeforoperatingleaseliabilityfromnewleases" name="Rightofuseassetobtainedinexchangeforoperatingleaseliabilityfromnewleases" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element name="UtilityEquipmentMember" id="iova_UtilityEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="TenantImprovementAllowanceReimbursementReceived" id="iova_TenantImprovementAllowanceReimbursementReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CashCashEquivalentsInvestmentsAndFairValueMeasurementsAbstract" id="iova_CashCashEquivalentsInvestmentsAndFairValueMeasurementsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RestrictedStockUnitsRsusAndPerformanceBasedRestrictedStockUnitsPrsusMember" id="iova_RestrictedStockUnitsRsusAndPerformanceBasedRestrictedStockUnitsPrsusMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LetterOfCreditForCommercialManufacturingFacilityMember" id="iova_LetterOfCreditForCommercialManufacturingFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LetterOfCreditForBenefitOfLandlordForHeadquartersLeaseMember" id="iova_LetterOfCreditForBenefitOfLandlordForHeadquartersLeaseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DecreaseInLettersOfCreditOnLeaseExpiration" id="iova_DecreaseInLettersOfCreditOnLeaseExpiration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="MinimumRestrictedSecurityDeposit" id="iova_MinimumRestrictedSecurityDeposit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="SponsoredResearchAgreementMember" id="iova_SponsoredResearchAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="FirstWuxiManufacturingAndServicesAgreementMember" id="iova_FirstWuxiManufacturingAndServicesAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="SecondWuxiManufacturingAndServicesAgreementMember" id="iova_SecondWuxiManufacturingAndServicesAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AdjustmentToAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationsNet" id="iova_AdjustmentToAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationsNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="SecondSalesAgreementMember" id="iova_SecondSalesAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsVestedAndExpectedToVestOutstandingNumber" id="iova_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsVestedAndExpectedToVestOutstandingNumber" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsVestedAndExpectedToVestOutstandingWeightedAverageGrantDateFairValue" id="iova_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentOtherThanOptionsVestedAndExpectedToVestOutstandingWeightedAverageGrantDateFairValue" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="PerformanceBasedRestrictedStockUnitMember" id="iova_PerformanceBasedRestrictedStockUnitMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DeferredTaxAssetsCapitalizedResearchAndDevelopment" id="iova_DeferredTaxAssetsCapitalizedResearchAndDevelopment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="SalesAgreement2023Member" id="iova_SalesAgreement2023Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ProleukinMember" id="iova_ProleukinMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AssetAcquisitionPaymentForCertainInventory" id="iova_AssetAcquisitionPaymentForCertainInventory" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AssembledWorkforceMember" id="iova_AssembledWorkforceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AssetAcquisitionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCash" id="iova_AssetAcquisitionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCash" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AssetAcquisitionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory" id="iova_AssetAcquisitionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AssetAcquisitionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" id="iova_AssetAcquisitionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AssetAcquisitionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiability" id="iova_AssetAcquisitionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AssetAcquisitionDeferredConsiderationTerm" id="iova_AssetAcquisitionDeferredConsiderationTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NetProceedsFromPublicOffering" id="iova_NetProceedsFromPublicOffering" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="SecurityDepositForFutureMilestonePaymentInAssetAcquisition" id="iova_SecurityDepositForFutureMilestonePaymentInAssetAcquisition" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="SupplyAgreementAutomaticRenewalTerm" id="iova_SupplyAgreementAutomaticRenewalTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="InventoriesAndCostOfSalesPolicyTextBlock" id="iova_InventoriesAndCostOfSalesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="AdjustmentsToAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationNetShares" id="iova_AdjustmentsToAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationNetShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NumberOfHistoricalAssetPurchaseAgreement" id="iova_NumberOfHistoricalAssetPurchaseAgreement" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="NumberOfHistoricalMasterCellBankLicenseAndWorkingCellBankTransferAgreement" id="iova_NumberOfHistoricalMasterCellBankLicenseAndWorkingCellBankTransferAgreement" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="NumberOfHistoricalLicenseAgreement" id="iova_NumberOfHistoricalLicenseAgreement" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="LicenseAgreementMilestonePaymentsPayable" id="iova_LicenseAgreementMilestonePaymentsPayable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LicenseAgreementMilestonePayment" id="iova_LicenseAgreementMilestonePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ManufacturingAndSupplyAgreementWithBoehringerIngelheimBiopharmaceuticalsGmbhMember" id="iova_ManufacturingAndSupplyAgreementWithBoehringerIngelheimBiopharmaceuticalsGmbhMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LicenseAgreementPercentOfMilestonePaymentsReimbursable" id="iova_LicenseAgreementPercentOfMilestonePaymentsReimbursable" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NovartisPharmaAgAndRelatedEntitiesLicenseAgreementMember" id="iova_NovartisPharmaAgAndRelatedEntitiesLicenseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PatentLicenseAgreementRelatedToDevelopmentAndManufactureOfTilTherapiesMember" id="iova_PatentLicenseAgreementRelatedToDevelopmentAndManufactureOfTilTherapiesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AccruedInventoryCurrent" id="iova_AccruedInventoryCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeArrangementAmountRequiredToBeRemitted" id="iova_CollaborativeArrangementAmountRequiredToBeRemitted" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CollaborativeArrangementPeriodToRemitRequiredAmount" id="iova_CollaborativeArrangementPeriodToRemitRequiredAmount" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DeferredTaxLiabilitiesRightOfUseAssets" id="iova_DeferredTaxLiabilitiesRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="PaymentsOfContingentConsiderationForAssetAcquisition" id="iova_PaymentsOfContingentConsiderationForAssetAcquisition" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="CustomerPaymentTerm" id="iova_CustomerPaymentTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LicenseAgreementAmortizationOfMilestonePayment" id="iova_LicenseAgreementAmortizationOfMilestonePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ProceedsFromIssuanceOfCommonStockUnderEmployeeStockPurchasePlan" id="iova_ProceedsFromIssuanceOfCommonStockUnderEmployeeStockPurchasePlan" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="SecondAmendedAndRestatedPatentLicenseAgreementMember" id="iova_SecondAmendedAndRestatedPatentLicenseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AmtagviMember" id="iova_AmtagviMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ScheduleOfGrossToNetAdjustmentsInRevenueTableTextBlock" id="iova_ScheduleOfGrossToNetAdjustmentsInRevenueTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="RevenueFromContractWithCustomerGross" id="iova_RevenueFromContractWithCustomerGross" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="RevenueFromContractWithCustomerGrossToNetAdjustmentsAbstract" id="iova_RevenueFromContractWithCustomerGrossToNetAdjustmentsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AdjustmentsForGovernmentRebatesAndChargebacks" id="iova_AdjustmentsForGovernmentRebatesAndChargebacks" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AdjustmentsForWholesalerFeesAndCashDiscounts" id="iova_AdjustmentsForWholesalerFeesAndCashDiscounts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AdjustmentsForOtherRebatesReturnsDiscountsAndAdjustments" id="iova_AdjustmentsForOtherRebatesReturnsDiscountsAndAdjustments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="RevenueFromContractWithCustomerGrossToNetAdjustments" id="iova_RevenueFromContractWithCustomerGrossToNetAdjustments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CustomerMember" id="iova_CustomerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="OtherCustomersMember" id="iova_OtherCustomersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NumberOfPatientsToBeTreatedAnnually" id="iova_NumberOfPatientsToBeTreatedAnnually" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ThresholdForConcentrationOfCreditRisk" id="iova_ThresholdForConcentrationOfCreditRisk" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="SharesIssuedInBreachOfFiduciaryDuty" id="iova_SharesIssuedInBreachOfFiduciaryDuty" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ResearchAndDevelopmentAgreementRequiredQuarterlyPayment" id="iova_ResearchAndDevelopmentAgreementRequiredQuarterlyPayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ThroughEndOf2024Member" id="iova_ThroughEndOf2024Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CommencingIn2025AndEndOfAgreementTermMember" id="iova_CommencingIn2025AndEndOfAgreementTermMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PatentLicenseAgreementRelatedToPhase2ClinicalStudyInMelanomaMember" id="iova_PatentLicenseAgreementRelatedToPhase2ClinicalStudyInMelanomaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PatentLicenseAgreementRelatedToApprovalOfAmtagviMember" id="iova_PatentLicenseAgreementRelatedToApprovalOfAmtagviMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PatentLicenseAgreementRelatedToApprovalOfFirstCommercialSaleOfAmtagviMember" id="iova_PatentLicenseAgreementRelatedToApprovalOfFirstCommercialSaleOfAmtagviMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PaymentsForAssetAcquisitionIncludingContingentConsiderationNetOfCashAcquired" id="iova_PaymentsForAssetAcquisitionIncludingContingentConsiderationNetOfCashAcquired" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ImpairmentOfLongLivedAssetsDueToEarlyTerminationOfLease" id="iova_ImpairmentOfLongLivedAssetsDueToEarlyTerminationOfLease" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DebtSecuritiesAvailableForSaleAllowanceForCreditLossImpairmentLoss" id="iova_DebtSecuritiesAvailableForSaleAllowanceForCreditLossImpairmentLoss" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="SingleReportableSegmentMember" id="iova_SingleReportableSegmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AcquisitionRelatedCostOfGoodsAndServicesSold" id="iova_AcquisitionRelatedCostOfGoodsAndServicesSold" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="SegmentReportingAmountOfIncreaseDecreaseOfOperatingProfitLossFromSegmentToConsolidatedAbstract" id="iova_SegmentReportingAmountOfIncreaseDecreaseOfOperatingProfitLossFromSegmentToConsolidatedAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="IncreaseDecreaseInRevenueFromContractWithCustomerExcludingAssessedTax" id="iova_IncreaseDecreaseInRevenueFromContractWithCustomerExcludingAssessedTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="IncreaseDecreaseInCostOfRevenue" id="iova_IncreaseDecreaseInCostOfRevenue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IncreaseDecreaseInResearchAndDevelopmentExpense" id="iova_IncreaseDecreaseInResearchAndDevelopmentExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IncreaseDecreaseInGeneralAndAdministrativeExpense" id="iova_IncreaseDecreaseInGeneralAndAdministrativeExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IncreaseDecreaseInSellingAndMarketingExpense" id="iova_IncreaseDecreaseInSellingAndMarketingExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IncreaseDecreaseInSegmentReportingOtherSegmentItemAmount" id="iova_IncreaseDecreaseInSegmentReportingOtherSegmentItemAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IncreaseDecreaseInOperatingExpenses" id="iova_IncreaseDecreaseInOperatingExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IncreaseDecreaseInNetIncomeLoss" id="iova_IncreaseDecreaseInNetIncomeLoss" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="SegmentReportingPercentageOfIncreaseDecreaseOfOperatingProfitLossFromSegmentToConsolidatedAbstract" id="iova_SegmentReportingPercentageOfIncreaseDecreaseOfOperatingProfitLossFromSegmentToConsolidatedAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PercentageOfIncreaseDecreaseInCostOfRevenue" id="iova_PercentageOfIncreaseDecreaseInCostOfRevenue" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PercentageOfIncreaseDecreaseInResearchAndDevelopmentExpense" id="iova_PercentageOfIncreaseDecreaseInResearchAndDevelopmentExpense" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PercentageOfIncreaseDecreaseInGeneralAndAdministrativeExpense" id="iova_PercentageOfIncreaseDecreaseInGeneralAndAdministrativeExpense" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PercentageOfIncreaseDecreaseInSellingAndMarketingExpense" id="iova_PercentageOfIncreaseDecreaseInSellingAndMarketingExpense" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PercentageOfIncreaseDecreaseInSegmentReportingOtherSegmentItemAmount" id="iova_PercentageOfIncreaseDecreaseInSegmentReportingOtherSegmentItemAmount" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PercentageOfIncreaseDecreaseInOperatingExpenses" id="iova_PercentageOfIncreaseDecreaseInOperatingExpenses" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="PercentageOfIncreaseDecreaseInNetIncomeLoss" id="iova_PercentageOfIncreaseDecreaseInNetIncomeLoss" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="SubLeaseAgreementMember" id="iova_SubLeaseAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LesseeOperatingLeaseNumberOfOptionsToExtendLease" id="iova_LesseeOperatingLeaseNumberOfOptionsToExtendLease" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="LesseeOperatingLeaseExtensionPercentageOfIncreaseInMonthlyBaseRent" id="iova_LesseeOperatingLeaseExtensionPercentageOfIncreaseInMonthlyBaseRent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="LesseeOperatingLeaseMonthlyBaseRent" id="iova_LesseeOperatingLeaseMonthlyBaseRent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="AreaOfLandSurrendered" id="iova_AreaOfLandSurrendered" type="dtr-types:areaItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="LesseeOperatingLeaseAmountOfEarlyLeaseTerminationFeesPaid" id="iova_LesseeOperatingLeaseAmountOfEarlyLeaseTerminationFeesPaid" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="LesseeOperatingLeaseAmountOfBrokerageFeePaid" id="iova_LesseeOperatingLeaseAmountOfBrokerageFeePaid" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DerecognitionOfOperatingLeaseRightOfUseAssets" id="iova_DerecognitionOfOperatingLeaseRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DerecognitionOfOperatingLeaseLiabilities" id="iova_DerecognitionOfOperatingLeaseLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="PercentageOfIncreaseDecreaseInRevenueFromContractWithCustomerExcludingAssessedTax" id="iova_PercentageOfIncreaseDecreaseInRevenueFromContractWithCustomerExcludingAssessedTax" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LossBeforeProvisionOfIncomeTaxesOfU.s.Losses" id="iova_LossBeforeProvisionOfIncomeTaxesOfU.s.Losses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="LossBeforeProvisionOfIncomeTaxesOfForeignLosses" id="iova_LossBeforeProvisionOfIncomeTaxesOfForeignLosses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
</xsd:schema>
