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  <xsd:element id="iova_AvailableForSaleDebtSecuritiesMaturityRollingAfterOneThroughTwoYearsFairValue" name="AvailableForSaleDebtSecuritiesMaturityRollingAfterOneThroughTwoYearsFairValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="iova_AvailableForSaleDebtSecuritiesMaturityRollingAfterOneThroughTwoYearsAmortizedCost" name="AvailableForSaleDebtSecuritiesMaturityRollingAfterOneThroughTwoYearsAmortizedCost" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="iova_DebtInstrumentAmountThatWillBeForgivenByLenderPerFullTimeOrFullTimeEquivalentEmployee" name="DebtInstrumentAmountThatWillBeForgivenByLenderPerFullTimeOrFullTimeEquivalentEmployee" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="iova_ThresholdAverageSalaryOfFullTimeEmployeesForLoanForgiveness" name="ThresholdAverageSalaryOfFullTimeEmployeesForLoanForgiveness" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="iova_DebtInstrumentTermOverWhichAverageNumberOfFTEmployeesEmployedAreCalculated" name="DebtInstrumentTermOverWhichAverageNumberOfFTEmployeesEmployedAreCalculated" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="iova_WeightedAveragePricePerShare" name="WeightedAveragePricePerShare" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="iova_MoffittLicenseAgreementTwoAmendedAndRestatedMember" name="MoffittLicenseAgreementTwoAmendedAndRestatedMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_TwoThousandTwentyOneInducementPlanMember" name="TwoThousandTwentyOneInducementPlanMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="iova_CashCashEquivalentsAndShortTermInvestmentsAndRestrictedCashTotal" name="CashCashEquivalentsAndShortTermInvestmentsAndRestrictedCashTotal" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="iova_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiabilityFromLeaseModifications" name="RightOfUseAssetObtainedInExchangeForOperatingLeaseLiabilityFromLeaseModifications" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="iova_Rightofuseassetobtainedinexchangeforoperatingleaseliabilityfromnewleases" name="Rightofuseassetobtainedinexchangeforoperatingleaseliabilityfromnewleases" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element name="UtilityEquipmentMember" id="iova_UtilityEquipmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="CashEquivalentsFairValueDisclosure" id="iova_CashEquivalentsFairValueDisclosure" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="TenantImprovementAllowanceReimbursementReceived" id="iova_TenantImprovementAllowanceReimbursementReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="FutureTenantImprovementReimbursement" id="iova_FutureTenantImprovementReimbursement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
</xsd:schema>
