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  <element name="RestrictedStockAwardsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_RestrictedStockAwardsMember" />

  <element name="NewYorkLeaseMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_NewYorkLeaseMember" />

  <element name="LicensesAndAgreementsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_LicensesAndAgreementsAbstract" />

  <element name="LicensesAndAgreementsDisclosureTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_LicensesAndAgreementsDisclosureTextBlock" />

  <element name="MoffittLicenseAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_MoffittLicenseAgreementMember" />

  <element name="KarolinskauniversityhospitalMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_KarolinskauniversityhospitalMember" />

  <element name="PaymentsForUpfrontLicensingFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_PaymentsForUpfrontLicensingFee" />

  <element name="PaymentsForClinicalTrialsAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_PaymentsForClinicalTrialsAgreement" />

  <element name="PaymentForUpfrontExclusiveLicense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_PaymentForUpfrontExclusiveLicense" />

  <element name="AdditionalMilesonePayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_AdditionalMilesonePayable" />

  <element name="NumberOfUnregisteredCommonStockToBeIssued" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="iova_NumberOfUnregisteredCommonStockToBeIssued" />

  <element name="ReimbursementinRelationToTransferOfKnowhow" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_ReimbursementinRelationToTransferOfKnowhow" />

  <element name="ClinicalTrialsManagementFeesPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_ClinicalTrialsManagementFeesPayable" />

  <element name="ConsultingFeesReceivable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="iova_ConsultingFeesReceivable" />

  <element name="InitialTermOfLicenceAgreement" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_InitialTermOfLicenceAgreement" />

  <element name="RepaymentsToBeMadeForTerminationOfLicenceAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_RepaymentsToBeMadeForTerminationOfLicenceAgreement" />

  <element name="PaymentsToBeMadeForOtherRelatedAgreements" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_PaymentsToBeMadeForOtherRelatedAgreements" />

  <element name="CommonStockRegisteredForResale" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_CommonStockRegisteredForResale" />

  <element name="SharesSoldUnderIneffectiveRegistration" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_SharesSoldUnderIneffectiveRegistration" />

  <element name="NumberOfShareOptionsOrShareUnitsExercisedDuringCurrentPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_NumberOfShareOptionsOrShareUnitsExercisedDuringCurrentPeriod" />

  <element name="SeriesBConvertiblePreferredStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_SeriesBConvertiblePreferredStockMember" />

  <element name="WarrantsAndRightsOutstandingRollforwardAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_WarrantsAndRightsOutstandingRollforwardAbstract" />

  <element name="WarrantsAndRightsGrantsInPeriodGross" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_WarrantsAndRightsGrantsInPeriodGross" />

  <element name="WarrantsAndRightsAdditionalDisclosuresAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_WarrantsAndRightsAdditionalDisclosuresAbstract" />

  <element name="EquityIncentivePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_EquityIncentivePlanMember" />

  <element name="RestrictedCommonStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_RestrictedCommonStockMember" />

  <element name="LegalAndRelatedServicesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_LegalAndRelatedServicesCurrent" />

  <element name="ClinicalRelatedExpensesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_ClinicalRelatedExpensesCurrent" />

  <element name="ManufacturingRelatedExpensesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_ManufacturingRelatedExpensesCurrent" />

  <element name="NationalCancerInstituteMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_NationalCancerInstituteMember" />

  <element name="AgreementTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_AgreementTerm" />

  <element name="CooperativeResearchAndDevelopmentAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_CooperativeResearchAndDevelopmentAgreementMember" />

  <element name="ConvertibleInstrumentsPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_ConvertibleInstrumentsPolicyTextBlock" />

  <element name="PolybioceptAbExclusiveAndCoexclusiveLicenseAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_PolybioceptAbExclusiveAndCoexclusiveLicenseAgreementMember" />

  <element name="FirstAnniversaryMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_FirstAnniversaryMember" />

  <element name="SatisfactionOfClinicalTrialMilestonesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_SatisfactionOfClinicalTrialMilestonesMember" />

  <element name="BlankCheckMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_BlankCheckMember" />

  <element name="OfferingCostsUnderAccountsPayableAndAccruedExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="iova_OfferingCostsUnderAccountsPayableAndAccruedExpenses" />

  <element name="ManufacturingAndServicesAgreementAmountPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_ManufacturingAndServicesAgreementAmountPayable" />

  <element name="WuxiApptechIncManufacturingAndServicesAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_WuxiApptechIncManufacturingAndServicesAgreementMember" />

  <element name="ManufacturingSuitesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_ManufacturingSuitesMember" />

  <element name="CommercialManufacturingCgmpSuiteMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_CommercialManufacturingCgmpSuiteMember" />

  <element name="SanCarlosLeaseMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_SanCarlosLeaseMember" />

  <element name="TeradataUsIncMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_TeradataUsIncMember" />

  <element name="ConsultingAgreementterm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_ConsultingAgreementterm" />

  <element name="StevenFischkoffMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_StevenFischkoffMember" />

  <element name="SeverancePayAndRetentionBonus" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_SeverancePayAndRetentionBonus" />

  <element name="TwoThousandElevenEquityIncentivePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_TwoThousandElevenEquityIncentivePlanMember" />

  <element name="ConsultingAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_ConsultingAgreementMember" />

  <element name="ProceedsFromIssuanceOfCommonStockGross" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="iova_ProceedsFromIssuanceOfCommonStockGross" />

  <element name="WarrantsAndRightsExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_WarrantsAndRightsExercised" />

  <element name="WarrantsAndRightsForfeituresAndExpirationsInPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_WarrantsAndRightsForfeituresAndExpirationsInPeriod" />

  <element name="WarrantsAndRightsOutstandingWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="iova_WarrantsAndRightsOutstandingWeightedAverageExercisePrice" />

  <element name="WarrantsAndRightsGrantsInPeriodWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_WarrantsAndRightsGrantsInPeriodWeightedAverageExercisePrice" />

  <element name="WarrantsAndRightsExercisesInPeriodWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_WarrantsAndRightsExercisesInPeriodWeightedAverageExercisePrice" />

  <element name="WarrantsAndRightsExpirationsInPeriodWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_WarrantsAndRightsExpirationsInPeriodWeightedAverageExercisePrice" />

  <element name="WarrantsAndRightsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="iova_WarrantsAndRightsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue" />

  <element name="WarrantsAndRightsOutstandingWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_WarrantsAndRightsOutstandingWeightedAverageRemainingContractualTerm" />
</schema>

