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  <element name="ConvertiblePricePerShares" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_ConvertiblePricePerShares" />

  <element name="TampaLeaseMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_TampaLeaseMember" />

  <element name="SharesIssuedPlanDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_SharesIssuedPlanDomain" />

  <element name="LeaseExpirationTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_LeaseExpirationTerm" />

  <element name="PaymentsForLegalServices" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_PaymentsForLegalServices" />

  <element name="SolomonCapitalLlcMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_SolomonCapitalLlcMember" />

  <element name="RestrictedStockAwardsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_RestrictedStockAwardsMember" />

  <element name="NewYorkLeaseMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_NewYorkLeaseMember" />

  <element name="LicensesAndAgreementsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_LicensesAndAgreementsAbstract" />

  <element name="LicensesAndAgreementsDisclosureTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_LicensesAndAgreementsDisclosureTextBlock" />

  <element name="ExclusivePatentLicenseAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_ExclusivePatentLicenseAgreementMember" />

  <element name="MoffittLicenseAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_MoffittLicenseAgreementMember" />

  <element name="KarolinskauniversityhospitalMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_KarolinskauniversityhospitalMember" />

  <element name="PaymentsForUpfrontLicensingFee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_PaymentsForUpfrontLicensingFee" />

  <element name="PaymentsForClinicalTrialsAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_PaymentsForClinicalTrialsAgreement" />

  <element name="PaymentForUpfrontExclusiveLicense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_PaymentForUpfrontExclusiveLicense" />

  <element name="AdditionalMilesonePayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_AdditionalMilesonePayable" />

  <element name="NumberOfUnregisteredCommonStockToBeIssued" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="iova_NumberOfUnregisteredCommonStockToBeIssued" />

  <element name="ReimbursementinRelationToTransferOfKnowhow" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_ReimbursementinRelationToTransferOfKnowhow" />

  <element name="ClinicalTrialsManagementFeesPayable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_ClinicalTrialsManagementFeesPayable" />

  <element name="ConsultingFeesReceivable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="iova_ConsultingFeesReceivable" />

  <element name="InitialTermOfLicenceAgreement" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_InitialTermOfLicenceAgreement" />

  <element name="RepaymentsToBeMadeForTerminationOfLicenceAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_RepaymentsToBeMadeForTerminationOfLicenceAgreement" />

  <element name="PaymentsToBeMadeForOtherRelatedAgreements" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_PaymentsToBeMadeForOtherRelatedAgreements" />

  <element name="CommonStockRegisteredForResale" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_CommonStockRegisteredForResale" />

  <element name="SharesSoldUnderIneffectiveRegistration" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_SharesSoldUnderIneffectiveRegistration" />

  <element name="NumberOfShareOptionsOrShareUnitsExercisedDuringCurrentPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_NumberOfShareOptionsOrShareUnitsExercisedDuringCurrentPeriod" />

  <element name="SeriesBConvertiblePreferredStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_SeriesBConvertiblePreferredStockMember" />

  <element name="EquityIncentivePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_EquityIncentivePlanMember" />

  <element name="RestrictedCommonStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_RestrictedCommonStockMember" />

  <element name="LegalAndRelatedServicesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_LegalAndRelatedServicesCurrent" />

  <element name="ClinicalRelatedExpensesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_ClinicalRelatedExpensesCurrent" />

  <element name="ManufacturingRelatedExpensesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_ManufacturingRelatedExpensesCurrent" />

  <element name="NationalCancerInstituteMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_NationalCancerInstituteMember" />

  <element name="CooperativeResearchAndDevelopmentAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_CooperativeResearchAndDevelopmentAgreementMember" />

  <element name="ConvertibleInstrumentsPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_ConvertibleInstrumentsPolicyTextBlock" />

  <element name="PolybioceptAbExclusiveAndCoexclusiveLicenseAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_PolybioceptAbExclusiveAndCoexclusiveLicenseAgreementMember" />

  <element name="FirstAnniversaryMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_FirstAnniversaryMember" />

  <element name="SatisfactionOfClinicalTrialMilestonesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_SatisfactionOfClinicalTrialMilestonesMember" />

  <element name="EqualMonthlyInstallmentsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_EqualMonthlyInstallmentsMember" />

  <element name="BlankCheckMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_BlankCheckMember" />

  <element name="LeaseholdImprovementsPaidByLandlord" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="iova_LeaseholdImprovementsPaidByLandlord" />

  <element name="SanCarlosLeaseMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_SanCarlosLeaseMember" />

  <element name="TeradataUsIncMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="iova_TeradataUsIncMember" />
</schema>

