Ownership Summary

Ownership Summary

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 307 3,792.93 103.49 131,254,766
Mutual Fund 290 1,140.61 30.89 39,033,392
Insider 5 15.93 0.65 818,448

* Insider values reflect direct beneficial ownership.

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 165 415.46 9.76 14,030,294
Sellers 141 -463.24 10.81 -15,542,008
Net -47.78 1.05 -1,511,714

Concentration

Value ($MM) % O/S Shares
Total Inst. 3,808.86 104.13 132,073,214
Top 10 Inst. 2,110.84 59.05 74,890,098
Top 20 Inst. 2,782.75 76.74 97,335,499
Top 50 Inst. 3,361.42 92.32 117,087,881

Style

Holders Value ($MM) % Inst Shares Shares
Growth 72 377.07 9.92 12,585,224
Aggressive Growth 7 19.38 0.50 638,213
Core Growth 52 314.81 8.29 10,520,615
Growth 13 42.89 1.12 1,426,396
Income 3 166.24 4.38 5,558,360
Income Value 2 165.83 4.37 5,539,739
Yield 1 0.40 0.01 18,621
Index 29 915.84 24.09 30,557,798
Other 108 2,014.28 56.60 71,778,236
Broker Dealer 18 133.75 3.52 4,467,968
GARP 34 414.17 10.96 13,902,395
Hedge Fund 48 536.90 14.18 17,982,632
Specialty 3 11.33 0.30 378,447
VC Private Equity 4 752.04 23.27 29,498,468
Sector Specific 1 166.09 4.37 5,548,326
Value 40 239.24 6.38 8,092,609
Core Value 31 193.96 5.19 6,580,242
Deep Value 9 45.29 1.19 1,512,367

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Perceptive Advisors LLC 11,670,057 9.20 2,253,855 3/31/20
The Vanguard Group, Inc. 11,129,211 8.77 276,082 3/31/20
Avoro Capital Advisors LLC 9,010,413 7.10 184,374 3/31/20
BlackRock Institutional Trust Company, N.A. 8,336,571 6.57 -161,123 3/31/20
Quogue Capital L.L.C. 7,067,333 5.59 -- 4/18/19
T. Rowe Price Associates, Inc. 6,780,431 5.34 270,575 3/31/20
Farallon Capital Management, L.L.C. 5,750,000 4.53 -500,000 3/31/20
OrbiMed Advisors, LLC 5,548,326 4.37 -- 3/31/20
Franklin Advisers, Inc. 5,199,585 4.10 -248,471 3/31/20
State Street Global Advisors (US) 4,398,171 3.47 73,995 3/31/20

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 3,331,012 2.32 58,482 3/31/20
Vanguard Small-Cap Index Fund 2,903,640 2.02 4,563 2/29/20
iShares Russell 2000 ETF 2,519,750 1.75 -104,122 4/30/20
T. Rowe Price New Horizons Fund 2,457,722 1.71 -66,300 3/31/20
T. Rowe Price Health Sciences Fund 2,429,327 1.69 -130,594 3/31/20
Franklin Templeton Investment Funds -Biotechnology Discovery 1,927,854 1.34 -- 4/30/20
Credit Suisse (Lux) Digital Health Equity Fund 1,800,000 1.25 -- 1/31/19
SPDR S&P Biotech ETF 1,773,022 1.23 -220,343 4/30/20
Vanguard Small-Cap Value Index Fund 1,767,600 1.23 14,097 2/29/20
Vanguard Extended Market Index Fund 1,657,908 1.15 6,625 3/31/20

Location: Global Region

Holders % O/S Shares Share Value
North America 247 100.17 127,049,043 3,662,171,144
Europe 48 3.88 4,922,697 143,705,649
Asia / Pacific 14 0.07 94,354 2,849,922
Africa 1 0.01 6,861 124,870
Latin America 1 -- 259 7,169

Location: Country

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