Ownership Summary

Ownership Summary

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 348 5,322.41 105.60 154,904,558
Mutual Fund 394 2,020.18 36.20 52,819,473
Insider 5 26.57 0.59 870,001

* Insider values reflect direct beneficial ownership.

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 165 625.38 10.89 15,975,515
Sellers 213 -493.10 10.40 -15,258,537
Net 132.27 0.49 716,978

Concentration

Value ($MM) % O/S Shares
Total Inst. 5,354.19 106.30 155,929,645
Top 10 Inst. 3,117.57 60.40 88,602,632
Top 20 Inst. 4,026.99 78.72 115,467,614
Top 50 Inst. 4,775.79 94.36 138,410,212

Style

Holders Value ($MM) % Inst Shares Shares
Growth 78 1,371.02 23.62 34,641,454
Aggressive Growth 8 23.24 0.47 692,233
Core Growth 54 603.62 12.01 17,611,067
Growth 16 744.16 11.14 16,338,154
Income 9 284.94 5.89 8,646,955
Income Value 2 282.07 5.84 8,568,432
Yield 7 2.87 0.05 78,523
Index 30 916.09 18.96 27,816,185
Other 122 2,479.53 51.45 75,465,872
Broker Dealer 24 168.44 3.49 5,116,754
GARP 34 512.18 10.53 15,450,965
Hedge Fund 55 634.49 13.20 19,361,764
Specialty 3 16.60 0.34 504,348
VC Private Equity 5 929.06 19.35 28,386,941
Sector Specific 1 218.76 4.53 6,645,100
Value 46 210.00 4.48 6,571,991
Core Value 39 171.44 3.68 5,400,562
Deep Value 7 38.56 0.80 1,171,429

Top Holders

Holder Shares Held % O/S Share Change Filing Date
ARK Investment Management LLC 15,297,822 10.43 7,394,514 12/31/20
The Vanguard Group, Inc. 11,778,527 8.03 -449,943 9/30/20
Perceptive Advisors LLC 10,085,632 6.88 -1,723,862 9/30/20
Avoro Capital Advisors LLC 9,536,039 6.50 -825,000 9/30/20
Franklin Advisers, Inc. 8,283,853 5.65 1,355,911 9/30/20
Quogue Capital L.L.C. 7,067,333 4.82 -- 4/16/20
BlackRock Institutional Trust Company, N.A. 7,024,112 4.79 -354,249 9/30/20
T. Rowe Price Associates, Inc. 6,929,214 4.72 -343,216 9/30/20
OrbiMed Advisors, LLC 6,645,100 4.53 -- 9/30/20
Farallon Capital Management, L.L.C. 5,955,000 4.06 -582,500 9/30/20

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
ARK Innovation ETF 8,632,474 5.88 1,888,732 12/31/20
ARK Genomic Revolution ETF 5,868,750 4.00 2,464,692 12/31/20
Vanguard Total Stock Market Index Fund 3,740,022 2.55 10,210 12/31/20
Hartford MidCap Fund 3,232,380 2.20 1,028,066 11/30/20
Vanguard Small-Cap Index Fund 3,129,198 2.13 21,583 12/31/20
T. Rowe Price Health Sciences Fund 2,408,669 1.64 -68,973 9/30/20
T. Rowe Price New Horizons Fund 2,303,856 1.57 -216,441 9/30/20
Franklin Templeton Investment Funds -Biotechnology Discovery 2,142,654 1.46 -- 11/30/20
Franklin DynaTech Fund 2,000,000 1.36 -- 11/30/20
Vanguard Extended Market Index Fund 1,914,248 1.31 101,366 12/31/20

Location: Global Region

Holders % O/S Shares Share Value
North America 273 98.07 143,858,861 4,934,645,904
Europe 62 5.46 8,010,824 284,883,254
Asia / Pacific 15 2.52 3,699,493 122,725,232
Middle East 2 0.24 353,000 11,620,760
Africa 1 -- 6,901 189,432
Latin America 1 -- 566 16,454

Location: Country

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