Ownership Summary

Ownership Summary

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 362 4,086.91 100.39 147,008,885
Mutual Fund 373 1,487.49 32.16 46,801,545
Insider 5 26.57 0.59 870,001

* Insider values reflect direct beneficial ownership.

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 205 803.53 19.96 29,224,489
Sellers 166 -551.09 13.37 -19,572,865
Net 252.44 6.59 9,651,624

Concentration

Value ($MM) % O/S Shares
Total Inst. 4,114.06 101.00 147,900,336
Top 10 Inst. 2,241.92 54.94 80,462,942
Top 20 Inst. 2,977.94 73.25 107,275,801
Top 50 Inst. 3,634.95 89.36 130,857,828

Style

Holders Value ($MM) % Inst Shares Shares
Growth 78 602.10 14.85 21,749,655
Aggressive Growth 8 21.45 0.52 763,125
Core Growth 55 437.53 10.79 15,796,438
Growth 15 143.13 3.54 5,190,092
Income 10 199.11 4.95 7,254,123
Income Value 2 197.67 4.92 7,201,237
Yield 8 1.43 0.04 52,886
Index 31 777.10 19.31 28,276,647
Other 131 2,289.50 55.90 81,866,465
Broker Dealer 26 181.77 4.52 6,619,532
GARP 37 453.77 11.12 16,285,130
Hedge Fund 60 586.59 14.54 21,287,813
Specialty 3 13.12 0.33 478,025
VC Private Equity 4 871.84 20.86 30,550,865
Sector Specific 1 182.41 4.54 6,645,100
Value 45 180.27 4.46 6,532,534
Core Value 39 145.51 3.60 5,266,156
Deep Value 6 34.76 0.86 1,266,378

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Vanguard Group, Inc. 12,228,470 8.35 1,099,259 6/30/20
Perceptive Advisors LLC 11,809,494 8.06 139,437 6/30/20
Avoro Capital Advisors LLC 10,361,039 7.08 1,350,626 6/30/20
BlackRock Institutional Trust Company, N.A. 7,378,361 5.04 -958,210 6/30/20
T. Rowe Price Associates, Inc. 7,272,430 4.97 491,999 6/30/20
Quogue Capital L.L.C. 7,067,333 4.83 -- 4/16/20
Franklin Advisers, Inc. 6,927,942 4.73 1,728,357 6/30/20
OrbiMed Advisors, LLC 6,645,100 4.54 1,096,774 6/30/20
Farallon Capital Management, L.L.C. 6,537,500 4.46 787,500 6/30/20
ARK Investment Management LLC 4,235,273 2.89 3,348,094 6/30/20

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
ARK Innovation ETF 4,989,483 3.41 485,803 9/30/20
Vanguard Total Stock Market Index Fund 3,648,212 2.49 -50,090 8/31/20
Vanguard Small-Cap Index Fund 3,069,359 2.10 -112,352 9/30/20
T. Rowe Price Health Sciences Fund 2,408,669 1.64 -68,973 9/30/20
ARK Genomic Revolution ETF 2,400,736 1.64 141,204 9/30/20
T. Rowe Price New Horizons Fund 2,303,856 1.57 -216,441 9/30/20
Franklin DynaTech Fund 2,000,000 1.37 300,000 9/30/20
Vanguard Extended Market Index Fund 1,889,650 1.29 -14,540 8/31/20
Franklin Templeton Investment Funds -Biotechnology Discovery 1,880,354 1.28 -- 9/30/20
Vanguard Small-Cap Value Index Fund 1,792,353 1.22 -144,595 9/30/20

Location: Global Region

Holders % O/S Shares Share Value
North America 288 94.55 138,454,905 3,843,425,905
Europe 55 4.19 6,140,705 179,494,507
Asia / Pacific 21 2.01 2,949,473 81,387,202
Middle East 1 0.24 348,000 9,552,600
Africa 1 -- 6,687 185,096
Latin America 1 -- 566 18,163

Location: Country

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