Ownership Summary

Ownership Summary

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 280 3,573.88 105.93 133,548,893
Mutual Fund 419 1,470.60 40.62 51,266,896
Insider 5 14.57 0.65 821,836

* Insider values reflect direct beneficial ownership.

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 154 299.73 8.58 10,849,303
Sellers 114 -285.85 8.49 -10,733,751
Net 13.88 0.09 115,552

Concentration

Value ($MM) % O/S Shares
Total Inst. 3,582.85 106.08 134,127,278
Top 10 Inst. 1,917.54 58.09 73,431,810
Top 20 Inst. 2,608.34 77.82 98,388,480
Top 50 Inst. 3,220.10 95.60 120,877,133

Style

Holders Value ($MM) % Inst Shares Shares
Growth 66 391.10 11.23 14,167,134
Aggressive Growth 7 17.64 0.51 649,402
Core Growth 49 339.89 9.75 12,304,754
Growth 10 33.58 0.96 1,212,978
Income 3 160.38 4.59 5,790,404
Income Value 2 159.75 4.57 5,771,344
Yield 1 0.63 0.02 19,060
Index 28 827.05 23.64 29,826,816
Other 97 1,941.06 59.08 74,419,276
Broker Dealer 17 130.33 3.73 4,708,426
GARP 29 349.17 10.10 12,744,902
Hedge Fund 42 635.92 18.21 22,981,226
Specialty 3 4.33 0.12 156,450
VC Private Equity 5 667.73 22.52 28,279,946
Sector Specific 1 153.58 4.40 5,548,326
Value 34 190.27 5.48 6,913,962
Core Value 26 166.01 4.78 6,035,758
Deep Value 8 24.27 0.70 878,204

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Vanguard Group, Inc. 10,853,129 8.60 324,949 12/31/19
Perceptive Advisors LLC 9,416,202 7.44 -1,598,500 12/31/19
Avoro Capital Advisors LLC 8,826,039 6.98 -1,775,000 12/31/19
BlackRock Institutional Trust Company, N.A. 8,497,694 6.73 158,515 12/31/19
Quogue Capital L.L.C. 7,067,333 5.59 -- 4/18/19
T. Rowe Price Associates, Inc. 6,509,856 5.15 4,773 12/31/19
Farallon Capital Management, L.L.C. 6,250,000 4.94 225,000 12/31/19
OrbiMed Advisors, LLC 5,548,326 4.39 -- 12/31/19
Franklin Advisers, Inc. 5,448,056 4.31 -1,082,120 12/31/19
Great Point Partners, LLC 5,015,175 3.96 -245,628 12/31/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 3,272,530 2.59 41,883 2/29/20
Vanguard Small-Cap Index Fund 2,903,640 2.30 4,563 2/29/20
T. Rowe Price Health Sciences Fund 2,559,921 2.02 -190,795 12/31/19
iShares Russell 2000 ETF 2,537,357 2.01 41,207 2/29/20
T. Rowe Price New Horizons Fund 2,524,022 2.00 -58,164 12/31/19
Franklin Templeton Investment Funds -Biotechnology Discovery 1,927,854 1.52 -62,400 2/29/20
SPDR S&P Biotech ETF 1,885,430 1.49 -31,494 2/29/20
Credit Suisse (Lux) Digital Health Equity Fund 1,800,000 1.42 -- 1/31/19
Vanguard Small-Cap Value Index Fund 1,767,600 1.40 14,097 2/29/20
Vanguard Extended Market Index Fund 1,651,283 1.31 -10,331 2/29/20

Location: Global Region

Holders % O/S Shares Share Value
North America 221 101.41 127,831,509 3,415,214,180
Europe 46 4.91 6,196,066 168,165,710
Asia / Pacific 15 0.27 336,034 4,935,244
Africa 1 0.01 6,861 124,870
Latin America 1 -- 259 5,473

Location: Country

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