Ownership Summary

Ownership Summary

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 276 3,531.04 104.73 132,027,511
Mutual Fund 407 1,175.86 39.27 49,466,265
Insider 5 12.52 0.66 823,157

* Insider values reflect direct beneficial ownership.

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 145 259.72 7.44 9,389,051
Sellers 116 -286.43 8.56 -10,800,907
Net -26.71 1.12 -1,411,856

Concentration

Value ($MM) % O/S Shares
Total Inst. 3,536.15 105.19 132,590,531
Top 10 Inst. 1,917.54 58.30 73,431,810
Top 20 Inst. 2,608.34 78.07 98,388,480
Top 50 Inst. 3,197.68 95.16 119,948,471

Style

Holders Value ($MM) % Inst Shares Shares
Growth 65 388.92 11.15 14,070,375
Aggressive Growth 7 17.91 0.51 647,368
Core Growth 48 337.43 9.68 12,210,029
Growth 10 33.58 0.96 1,212,978
Income 3 160.16 4.59 5,789,965
Income Value 2 159.75 4.57 5,771,344
Yield 1 0.40 0.01 18,621
Index 27 820.15 23.54 29,706,789
Other 96 1,944.81 59.10 74,448,316
Broker Dealer 17 130.33 3.73 4,708,426
GARP 28 352.92 10.12 12,773,942
Hedge Fund 42 635.92 18.21 22,981,226
Specialty 3 4.33 0.12 156,450
VC Private Equity 5 667.73 22.52 28,279,946
Sector Specific 1 153.58 4.40 5,548,326
Value 33 153.59 4.41 5,565,407
Core Value 25 129.29 3.71 4,687,203
Deep Value 8 24.31 0.70 878,204

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Vanguard Group, Inc. 10,853,129 8.60 324,949 12/31/19
Perceptive Advisors LLC 9,416,202 7.46 -1,598,500 12/31/19
Avoro Capital Advisors LLC 8,826,039 6.99 -1,775,000 12/31/19
BlackRock Institutional Trust Company, N.A. 8,497,694 6.73 158,515 12/31/19
Quogue Capital L.L.C. 7,067,333 5.71 -- 4/18/19
T. Rowe Price Associates, Inc. 6,509,856 5.16 4,773 12/31/19
Farallon Capital Management, L.L.C. 6,250,000 4.95 225,000 12/31/19
OrbiMed Advisors, LLC 5,548,326 4.40 -- 12/31/19
Franklin Advisers, Inc. 5,448,056 4.32 -1,082,120 12/31/19
Great Point Partners, LLC 5,015,175 3.97 -245,628 12/31/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 3,230,647 2.56 7,178 1/31/20
Vanguard Small-Cap Index Fund 2,899,077 2.30 52,615 1/31/20
T. Rowe Price Health Sciences Fund 2,559,921 2.03 -190,795 12/31/19
T. Rowe Price New Horizons Fund 2,524,022 2.00 -58,164 12/31/19
iShares Russell 2000 ETF 2,496,150 1.98 -190,442 1/31/20
Franklin Templeton Invest-Biotechnology Discovery 1,990,254 1.58 -313,325 1/31/20
SPDR S&P Biotech ETF 1,916,924 1.52 12,245 1/31/20
Credit Suisse (Lux) Digital Health Equity Fund 1,800,000 1.43 -- 1/31/19
Vanguard Small-Cap Value Index Fund 1,753,503 1.39 4,116 1/31/20
Franklin Biotechnology Discovery Fund 1,663,700 1.32 -232,100 12/31/19

Location: Global Region

Holders % O/S Shares Share Value
North America 219 101.30 127,683,308 3,408,015,297
Europe 44 3.83 4,828,309 130,466,416
Asia / Pacific 15 0.27 331,931 4,940,042
Africa 1 0.01 6,861 124,870
Latin America 1 -- 259 5,473

Location: Country

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