Ownership Summary

Ownership Summary

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 327 3,979.89 91.16 133,359,430
Mutual Fund 335 1,263.29 32.45 46,269,511
Insider 5 26.57 0.59 870,001

* Insider values reflect direct beneficial ownership.

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 172 451.04 10.48 15,336,559
Sellers 138 -454.99 10.47 -15,310,358
Net -3.96 0.02 26,201

Concentration

Value ($MM) % O/S Shares
Total Inst. 4,006.36 91.75 134,226,926
Top 10 Inst. 2,257.49 51.19 74,890,098
Top 20 Inst. 2,952.76 67.22 98,345,380
Top 50 Inst. 3,552.55 81.17 118,753,981

Style

Holders Value ($MM) % Inst Shares Shares
Growth 77 464.24 10.85 15,876,320
Aggressive Growth 8 18.69 0.43 632,047
Core Growth 53 393.15 9.20 13,454,780
Growth 16 52.41 1.22 1,789,493
Income 4 166.24 3.80 5,558,409
Income Value 2 165.83 3.79 5,539,739
Yield 2 0.41 0.01 18,670
Index 29 904.46 20.68 30,249,401
Other 112 2,179.86 49.66 72,651,726
Broker Dealer 20 153.37 3.51 5,131,165
GARP 33 429.17 9.88 14,451,252
Hedge Fund 51 537.57 12.36 18,081,734
Specialty 3 11.33 0.26 378,447
VC Private Equity 4 882.33 19.86 29,060,802
Sector Specific 1 166.09 3.79 5,548,326
Value 44 204.83 4.76 6,971,070
Core Value 35 159.42 3.73 5,452,058
Deep Value 9 45.41 1.04 1,519,012

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Perceptive Advisors LLC 11,670,057 7.98 2,253,855 3/31/20
The Vanguard Group, Inc. 11,129,211 7.61 276,082 3/31/20
Avoro Capital Advisors LLC 9,010,413 6.16 184,374 3/31/20
BlackRock Institutional Trust Company, N.A. 8,336,571 5.70 -161,123 3/31/20
Quogue Capital L.L.C. 7,067,333 4.83 -- 4/16/20
T. Rowe Price Associates, Inc. 6,780,431 4.63 270,575 3/31/20
Farallon Capital Management, L.L.C. 5,750,000 3.93 -500,000 3/31/20
OrbiMed Advisors, LLC 5,548,326 3.79 -- 3/31/20
Franklin Advisers, Inc. 5,199,585 3.55 -248,471 3/31/20
State Street Global Advisors (US) 4,398,171 3.01 73,995 3/31/20

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 3,698,733 2.53 15,292 6/30/20
Vanguard Small-Cap Index Fund 3,237,571 2.21 -70,276 6/30/20
T. Rowe Price New Horizons Fund 2,520,297 1.72 62,575 6/30/20
T. Rowe Price Health Sciences Fund 2,477,642 1.69 48,315 6/30/20
ARK Innovation ETF 2,208,239 1.51 2,208,239 6/30/20
SPDR S&P Biotech ETF 1,976,561 1.35 239,594 7/31/20
Vanguard Small-Cap Value Index Fund 1,944,759 1.33 -122,272 6/30/20
Vanguard Extended Market Index Fund 1,914,978 1.31 149,248 6/30/20
Franklin Templeton Investment Funds -Biotechnology Discovery 1,880,354 1.29 -47,500 6/30/20
Credit Suisse (Lux) Digital Health Equity Fund 1,800,000 1.23 -- 1/31/19

Location: Global Region

Holders % O/S Shares Share Value
North America 264 86.19 126,099,930 3,777,585,853
Europe 49 3.57 5,219,209 148,831,441
Asia / Pacific 16 1.98 2,903,039 79,836,234
Africa 1 -- 6,687 185,096
Latin America 1 -- 566 18,627

Location: Country

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