Ownership Summary

Ownership Summary

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 342 4,380.65 106.52 165,135,769
Mutual Fund 457 1,551.52 36.97 56,299,505
Insider 4 27.35 0.56 870,001

* Insider values reflect direct beneficial ownership.

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 188 743.53 18.49 28,666,191
Sellers 203 -744.37 18.14 -28,126,016
Net -0.84 0.35 540,175

Concentration

Value ($MM) % O/S Shares
Total Inst. 4,406.40 107.00 165,888,381
Top 10 Inst. 2,450.99 59.81 92,724,236
Top 20 Inst. 3,259.20 79.85 123,785,518
Top 50 Inst. 3,977.75 96.63 149,806,972

Style

Holders Value ($MM) % Inst Shares Shares
Growth 81 1,009.90 24.90 38,606,788
Aggressive Growth 7 29.56 0.68 1,052,405
Core Growth 61 486.18 11.97 18,562,433
Growth 13 494.16 12.25 18,991,950
Income 10 200.45 4.97 7,706,691
Income Value 3 197.15 4.89 7,576,897
Yield 7 3.30 0.08 129,794
Index 34 805.58 19.97 30,959,936
Other 111 1,912.02 46.63 72,296,903
Broker Dealer 26 103.01 2.55 3,949,479
GARP 31 344.55 8.73 13,539,728
Hedge Fund 45 465.69 11.54 17,894,690
Specialty 3 8.53 0.21 327,642
VC Private Equity 5 817.35 19.31 29,940,264
Sector Specific 1 172.91 4.29 6,645,100
Value 36 384.18 8.35 12,951,957
Core Value 33 362.96 7.83 12,136,619
Deep Value 3 21.22 0.53 815,338

Top Holders

Holder Shares Held % O/S Share Change Filing Date
ARK Investment Management LLC 18,450,713 11.90 -1,275,937 6/30/21
The Vanguard Group, Inc. 12,236,411 7.89 182,924 6/30/21
Perceptive Advisors LLC 10,959,772 7.07 2,307,987 6/30/21
Avoro Capital Advisors LLC 9,100,000 5.87 861,039 6/30/21
Nikko Asset Management Co., Ltd. 7,737,618 4.99 2,434,885 6/30/21
Wellington Management Company, LLP 7,251,243 4.68 3,586 6/30/21
Franklin Advisers, Inc. 7,183,701 4.63 -1,786,979 6/30/21
Quogue Capital L.L.C. 7,067,333 4.56 -- 4/19/21
OrbiMed Advisors, LLC 6,645,100 4.29 -- 6/30/21
BlackRock Institutional Trust Company, N.A. 6,092,345 3.93 -707,899 6/30/21

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
ARK Innovation ETF 6,629,637 4.28 -1,859,682 8/31/21
ARK Genomic Revolution ETF 6,104,301 3.94 -166,001 8/31/21
Hartford MidCap Fund 4,813,883 3.11 489,730 7/31/21
Nikko AM ARK Disruptive Innovation A USD 4,636,379 2.99 -57,410 6/30/21
Vanguard Total Stock Market Index Fund 3,675,991 2.37 -7,809 8/31/21
Vanguard Small-Cap Index Fund 3,242,396 2.09 6,420 8/31/21
Franklin Templeton Investment Funds -Biotechnology Discovery 2,419,535 1.56 255,900 6/30/21
SPDR S&P Biotech ETF 2,118,077 1.37 130,559 8/31/21
Vanguard Extended Market Index Fund 2,069,721 1.34 2,341 8/31/21
Vanguard Small-Cap Value Index Fund 2,015,178 1.30 -3,276 8/31/21

Location: Global Region

Holders % O/S Shares Share Value
North America 254 93.77 145,372,223 3,844,208,567
Europe 71 7.91 12,263,048 345,960,953
Asia / Pacific 19 5.19 8,046,667 209,390,865
Middle East 1 0.24 378,642 9,852,265
Africa 1 -- 3,116 98,653
Latin America 1 -- 74 3,434

Location: Country

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