Ownership Summary

Ownership Summary

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 356 2,744.69 103.59 162,806,846
Mutual Fund 462 990.71 34.59 54,188,012
Insider 5 9.53 0.40 628,714

* Insider values reflect direct beneficial ownership.

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 191 372.55 14.21 22,326,078
Sellers 169 -364.99 13.67 -21,478,224
Net 7.57 0.54 847,854

Concentration

Value ($MM) % O/S Shares
Total Inst. 2,764.81 105.33 165,550,772
Top 10 Inst. 1,390.97 53.56 84,178,455
Top 20 Inst. 1,887.32 72.53 113,989,312
Top 50 Inst. 2,389.93 91.36 143,584,467

Style

Holders Value ($MM) % Inst Shares Shares
Growth 83 352.16 13.20 20,747,635
Aggressive Growth 5 11.53 0.32 498,269
Core Growth 63 274.00 10.35 16,265,144
Growth 15 66.63 2.53 3,984,222
Income 10 100.45 3.83 6,019,340
Income Value 4 98.08 3.75 5,890,812
Yield 6 2.37 0.08 128,528
Index 32 559.25 21.35 33,554,554
Other 116 1,381.19 51.78 81,379,702
Broker Dealer 27 89.98 3.30 5,185,693
GARP 29 238.73 8.98 14,107,502
Hedge Fund 49 424.19 16.20 25,455,187
Specialty 4 7.31 0.28 438,843
VC Private Equity 6 510.54 18.81 29,559,471
Sector Specific 1 110.44 4.22 6,633,006
Value 40 288.02 10.81 16,995,785
Core Value 34 274.25 10.29 16,168,642
Deep Value 6 13.77 0.53 827,143

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Vanguard Group, Inc. 12,341,653 7.85 143,866 3/31/22
Perceptive Advisors LLC 12,201,261 7.76 2,073,320 3/31/22
Wellington Management Company, LLP 11,288,726 7.18 1,704,644 3/31/22
Avoro Capital Advisors LLC 9,125,000 5.81 450,000 3/31/22
Quogue Capital L.L.C. 7,067,333 4.50 -- 4/18/22
State Street Global Advisors (US) 6,845,726 4.36 1,752,044 3/31/22
OrbiMed Advisors, LLC 6,633,006 4.22 295,306 3/31/22
BlackRock Institutional Trust Company, N.A. 6,457,174 4.11 10,294 3/31/22
Farallon Capital Management, L.L.C. 6,175,357 3.93 113,384 3/31/22
Avidity Partners Management LP 6,043,219 3.85 2,263,219 3/31/22

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Hartford MidCap Fund 6,361,269 4.05 75,324 3/31/22
SPDR S&P Biotech ETF 4,554,493 2.90 27,835 4/30/22
Vanguard Total Stock Market Index Fund 3,931,023 2.50 -198,493 3/31/22
Vanguard Small-Cap Index Fund 3,339,848 2.13 -14,093 3/31/22
ARK Genomic Revolution ETF 2,918,768 1.86 -135,353 4/30/22
Franklin Templeton Investment Funds -Biotechnology Discovery 2,700,535 1.72 281,000 12/31/21
Credit Suisse (Lux) Digital Health Equity Fund 2,200,000 1.40 -- 3/31/22
Vanguard Small-Cap Value Index Fund 2,186,094 1.39 13,576 3/31/22
Vanguard Extended Market Index Fund 1,829,042 1.16 12,482 3/31/22
Artisan Small Cap Fund 1,732,418 1.10 5,438 3/31/22

Location: Global Region

Holders % O/S Shares Share Value
North America 274 93.92 147,613,113 2,457,134,108
Europe 69 9.49 14,908,651 256,951,249
Asia / Pacific 18 1.94 3,044,648 50,955,419
Africa 1 -- 3,371 83,129
Latin America 1 -- 74 3,434
Middle East -- -- -- --

Location: Country

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