Ownership Summary

Ownership Summary

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 344 4,089.02 104.20 161,546,505
Mutual Fund 463 1,418.67 35.89 55,372,120
Insider 4 27.35 0.56 870,001

* Insider values reflect direct beneficial ownership.

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 157 330.20 8.63 13,380,812
Sellers 193 -612.23 15.79 -24,474,109
Net -282.03 7.16 -11,093,297

Concentration

Value ($MM) % O/S Shares
Total Inst. 4,117.81 104.80 162,474,506
Top 10 Inst. 2,136.79 54.64 84,706,896
Top 20 Inst. 2,924.95 74.42 115,369,827
Top 50 Inst. 3,612.12 91.89 142,451,396

Style

Holders Value ($MM) % Inst Shares Shares
Growth 77 784.87 20.40 31,620,822
Aggressive Growth 5 22.61 0.53 822,370
Core Growth 58 464.08 12.07 18,706,877
Growth 14 298.18 7.80 12,091,575
Income 9 164.97 4.32 6,689,948
Income Value 3 162.18 4.24 6,576,491
Yield 6 2.80 0.07 113,457
Index 32 751.66 19.66 30,478,694
Other 112 1,908.89 48.64 75,407,309
Broker Dealer 25 82.36 2.15 3,339,841
GARP 28 318.58 8.30 12,870,080
Hedge Fund 50 530.53 13.87 21,504,975
Specialty 3 11.82 0.31 479,391
VC Private Equity 5 801.72 19.72 30,567,922
Sector Specific 1 163.87 4.29 6,645,100
Value 41 421.49 9.71 15,050,060
Core Value 35 394.39 9.00 13,950,822
Deep Value 6 27.10 0.71 1,099,238

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Vanguard Group, Inc. 11,928,989 7.69 -307,422 9/30/21
ARK Investment Management LLC 11,649,837 7.51 -6,800,876 9/30/21
Perceptive Advisors LLC 11,489,772 7.41 530,000 9/30/21
Wellington Management Company, LLP 8,899,530 5.74 1,648,287 9/30/21
Avoro Capital Advisors LLC 8,500,000 5.48 -600,000 9/30/21
Quogue Capital L.L.C. 7,067,333 4.56 -- 4/19/21
OrbiMed Advisors, LLC 6,645,100 4.29 -- 9/30/21
Nikko Asset Management Co., Ltd. 6,380,803 4.12 -1,356,815 9/30/21
Franklin Advisers, Inc. 6,238,692 4.02 -945,009 9/30/21
BlackRock Institutional Trust Company, N.A. 5,906,840 3.81 -185,505 9/30/21

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
ARK Genomic Revolution ETF 5,414,804 3.49 -462,021 10/31/21
ARK Innovation ETF 5,342,913 3.45 22,743 10/31/21
Hartford MidCap Fund 5,071,958 3.27 -61,376 10/31/21
Vanguard Total Stock Market Index Fund 3,706,294 2.39 3,600 10/31/21
Nikko AM ARK Disruptive Innovation A USD 3,367,686 2.17 -503,841 9/30/21
Vanguard Small-Cap Index Fund 3,292,826 2.12 13,299 10/31/21
Franklin Templeton Investment Funds -Biotechnology Discovery 2,419,535 1.56 -- 9/30/21
SPDR S&P Biotech ETF 2,388,462 1.54 -9,432 10/31/21
Credit Suisse (Lux) Digital Health Equity Fund 2,200,000 1.42 -- 5/31/21
Nikko AM ARK Positive Change Innovation Fund 2,127,407 1.37 70,114 9/30/21

Location: Global Region

Holders % O/S Shares Share Value
North America 263 91.48 141,829,138 3,572,173,270
Europe 66 8.69 13,473,401 368,732,104
Asia / Pacific 17 4.31 6,673,968 164,590,670
Middle East 1 0.32 494,809 12,201,990
Africa 1 -- 3,116 98,653
Latin America 1 -- 74 3,434

Location: Country

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