Ownership Summary

Ownership Summary

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 210 1,243.68 102.04 126,037,178
Mutual Fund 334 856.64 33.71 41,609,466
Insider 5 9.56 0.68 838,597

* Insider values reflect direct beneficial ownership.

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 90 92.84 6.66 8,221,744
Sellers 111 -129.91 10.88 -13,439,092
Net -37.07 4.22 -5,217,348

Concentration

Value ($MM) % O/S Shares
Total Inst. 1,253.24 102.72 126,875,775
Top 10 Inst. 709.14 59.23 73,163,401
Top 20 Inst. 948.62 79.62 98,345,625
Top 50 Inst. 1,163.80 95.90 118,451,410

Style

Holders Value ($MM) % Inst Shares Shares
Growth 44 111.16 7.78 9,613,639
Aggressive Growth 5 3.91 0.31 378,707
Core Growth 32 94.98 6.43 7,938,399
Growth 7 12.27 1.05 1,296,533
Income 3 81.66 6.93 8,557,202
Income Value 2 81.20 6.91 8,538,240
Yield 1 0.46 0.02 18,962
Index 25 221.55 18.46 22,800,710
Other 76 795.37 66.16 81,710,969
Broker Dealer 14 28.78 2.45 3,026,338
GARP 19 69.94 5.61 6,926,846
Hedge Fund 35 422.34 35.88 44,317,862
Specialty 2 0.87 0.07 91,917
VC Private Equity 5 220.67 17.65 21,799,680
Sector Specific 1 52.76 4.49 5,548,326
Value 27 14.56 1.23 1,517,028
Core Value 21 9.79 0.82 1,016,396
Deep Value 6 4.76 0.41 500,632

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Perceptive Advisors LLC 12,235,811 9.91 -5,494 3/31/19
Avoro Capital Advisors LLC 10,530,862 8.53 269,823 3/31/19
Franklin Advisers, Inc. 8,225,899 6.66 1,435 3/31/19
BlackRock Institutional Trust Company, N.A. 8,131,641 6.58 -7,865 3/31/19
Quogue Capital L.L.C. 7,067,333 5.72 -- 4/18/19
The Vanguard Group, Inc. 5,802,878 4.70 23,809 3/31/19
Farallon Capital Management, L.L.C. 5,725,000 4.64 -- 3/31/19
Great Point Partners, LLC 5,567,348 4.51 -- 3/31/19
OrbiMed Advisors, LLC 5,548,326 4.49 -- 3/31/19
Broadfin Capital, L.L.C. 4,328,303 3.50 -1,622,850 3/31/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Franklin Templeton Invest-Biotechnology Discovery 3,247,479 2.63 -191,700 6/30/19
Vanguard Total Stock Market Index Fund 3,145,206 2.55 239 6/30/19
T. Rowe Price Health Sciences Fund 2,588,816 2.10 793,000 6/30/19
T. Rowe Price New Horizons Fund 2,411,886 1.95 1,314,900 6/30/19
iShares Russell 2000 ETF 2,391,545 1.94 259,336 6/30/19
Franklin Small Cap Growth Fund 2,248,900 1.82 -- 5/31/19
Franklin Biotechnology Discovery Fund 2,102,800 1.70 -130,800 5/31/19
Credit Suisse (Lux) Glb Digital Health Equity Fd 1,800,000 1.46 -- 1/31/19
Vanguard Extended Market Index Fund 1,702,054 1.38 -8,610 6/30/19
Vanguard Small-Cap Index Fund 1,415,892 1.15 1,415,892 6/30/19

Location: Global Region

Holders % O/S Shares Share Value
North America 161 97.07 119,898,888 1,176,889,155
Europe 39 4.91 6,058,419 67,549,100
Asia / Pacific 13 0.74 913,177 8,738,284
Africa 1 -- 5,291 59,524

Location: Country

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