Ownership Summary

Ownership Summary

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 231 3,080.51 104.89 129,883,585
Mutual Fund 356 993.84 34.86 43,062,915
Insider 5 9.56 0.68 838,597

* Insider values reflect direct beneficial ownership.

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 127 544.97 17.96 22,240,316
Sellers 110 -447.33 15.30 -18,949,350
Net 97.65 2.66 3,290,966

Concentration

Value ($MM) % O/S Shares
Total Inst. 3,093.96 105.69 130,880,980
Top 10 Inst. 1,786.96 61.91 76,659,162
Top 20 Inst. 2,421.38 82.80 102,532,800
Top 50 Inst. 2,876.75 98.00 121,348,552

Style

Holders Value ($MM) % Inst Shares Shares
Growth 55 274.39 9.20 11,398,015
Aggressive Growth 7 12.83 0.42 523,055
Core Growth 38 232.47 7.67 9,502,890
Growth 10 29.09 1.11 1,372,070
Income 3 180.36 5.94 7,355,762
Income Value 2 179.88 5.92 7,336,041
Yield 1 0.48 0.02 19,721
Index 26 634.20 20.89 25,869,893
Other 82 1,864.20 64.51 79,879,565
Broker Dealer 18 97.56 3.21 3,978,939
GARP 23 274.72 9.07 11,226,292
Hedge Fund 33 906.51 29.89 37,018,460
Specialty 2 2.11 0.07 86,145
VC Private Equity 5 447.24 17.78 22,021,403
Sector Specific 1 136.04 4.48 5,548,326
Value 28 73.80 2.44 3,023,996
Core Value 22 57.31 1.90 2,351,710
Deep Value 6 16.48 0.54 672,286

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Perceptive Advisors LLC 11,915,127 9.62 -320,684 6/30/19
Avoro Capital Advisors LLC 10,752,585 8.68 221,723 6/30/19
The Vanguard Group, Inc. 8,491,841 6.86 2,688,963 6/30/19
BlackRock Institutional Trust Company, N.A. 8,268,929 6.68 137,288 6/30/19
Quogue Capital L.L.C. 7,067,333 5.71 -- 4/18/19
Franklin Advisers, Inc. 7,013,282 5.66 -1,212,617 6/30/19
T. Rowe Price Associates, Inc. 6,023,903 4.86 2,531,169 6/30/19
Consonance Capital Management LP 5,852,836 4.73 4,712,836 6/30/19
Farallon Capital Management, L.L.C. 5,725,000 4.62 -- 6/30/19
OrbiMed Advisors, LLC 5,548,326 4.48 -- 6/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 3,145,206 2.54 239 6/30/19
Franklin Templeton Invest-Biotechnology Discovery 3,016,579 2.44 -230,900 7/31/19
T. Rowe Price Health Sciences Fund 2,588,816 2.09 793,000 6/30/19
iShares Russell 2000 ETF 2,489,030 2.01 97,485 7/31/19
T. Rowe Price New Horizons Fund 2,411,886 1.95 1,314,900 6/30/19
Franklin Biotechnology Discovery Fund 1,990,500 1.61 -112,300 6/30/19
Credit Suisse (Lux) Digital Health Equity Fund 1,800,000 1.45 -- 1/31/19
Vanguard Extended Market Index Fund 1,702,054 1.37 -8,610 6/30/19
Fidelity Select Biotechnology Portfolio 1,638,818 1.32 794,930 6/30/19
Franklin Small Cap Growth Fund 1,612,500 1.30 -636,400 6/30/19

Location: Global Region

Holders % O/S Shares Share Value
North America 185 101.07 125,149,380 2,958,668,868
Europe 39 4.02 4,983,523 120,605,564
Asia / Pacific 11 0.56 687,988 13,291,757
Africa 1 -- 5,291 50,317

Location: Country

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