Ownership Summary

Ownership Summary

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 235 3,095.87 105.26 130,343,065
Mutual Fund 373 990.45 36.05 44,588,665
Insider 5 9.56 0.68 838,597

* Insider values reflect direct beneficial ownership.

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 130 549.03 18.09 22,405,228
Sellers 113 -447.52 15.26 -18,900,528
Net 101.50 2.83 3,504,700

Concentration

Value ($MM) % O/S Shares
Total Inst. 3,107.97 106.02 131,285,102
Top 10 Inst. 1,786.96 61.91 76,659,162
Top 20 Inst. 2,421.38 82.80 102,532,800
Top 50 Inst. 2,876.75 98.00 121,348,552

Style

Holders Value ($MM) % Inst Shares Shares
Growth 57 280.23 9.25 11,455,165
Aggressive Growth 7 12.82 0.42 522,615
Core Growth 40 235.04 7.74 9,585,330
Growth 10 32.37 1.09 1,347,220
Income 3 180.29 5.94 7,355,762
Income Value 2 179.88 5.92 7,336,041
Yield 1 0.41 0.02 19,721
Index 27 633.38 20.90 25,882,259
Other 85 1,868.41 64.64 80,049,692
Broker Dealer 18 97.56 3.21 3,978,939
GARP 25 278.95 9.20 11,397,910
Hedge Fund 34 906.50 29.89 37,016,969
Specialty 2 2.11 0.07 86,145
VC Private Equity 5 447.24 17.78 22,021,403
Sector Specific 1 136.04 4.48 5,548,326
Value 28 76.25 2.52 3,124,125
Core Value 22 59.77 1.98 2,451,839
Deep Value 6 16.48 0.54 672,286

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Perceptive Advisors LLC 11,915,127 9.62 -320,684 6/30/19
Avoro Capital Advisors LLC 10,752,585 8.68 221,723 6/30/19
The Vanguard Group, Inc. 8,491,841 6.86 2,688,963 6/30/19
BlackRock Institutional Trust Company, N.A. 8,268,929 6.68 137,288 6/30/19
Quogue Capital L.L.C. 7,067,333 5.71 -- 4/18/19
Franklin Advisers, Inc. 7,013,282 5.66 -1,212,617 6/30/19
T. Rowe Price Associates, Inc. 6,023,903 4.86 2,531,169 6/30/19
Consonance Capital Management LP 5,852,836 4.73 4,712,836 6/30/19
Farallon Capital Management, L.L.C. 5,725,000 4.62 -- 6/30/19
OrbiMed Advisors, LLC 5,548,326 4.48 -- 6/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 3,148,093 2.54 824 8/31/19
Franklin Templeton Invest-Biotechnology Discovery 3,016,579 2.44 -230,900 7/31/19
T. Rowe Price Health Sciences Fund 2,588,816 2.09 793,000 6/30/19
T. Rowe Price New Horizons Fund 2,411,886 1.95 1,314,900 6/30/19
iShares Russell 2000 ETF 2,390,018 1.93 -99,012 8/31/19
Franklin Biotechnology Discovery Fund 1,990,500 1.61 -- 7/31/19
Credit Suisse (Lux) Digital Health Equity Fund 1,800,000 1.45 -- 1/31/19
Vanguard Extended Market Index Fund 1,774,634 1.43 38,197 8/31/19
Vanguard Small-Cap Index Fund 1,758,397 1.42 329,471 8/31/19
Fidelity Select Biotechnology Portfolio 1,643,707 1.33 4,889 7/31/19

Location: Global Region

Holders % O/S Shares Share Value
North America 190 101.41 125,571,692 2,972,916,516
Europe 37 4.05 5,020,785 121,729,686
Asia / Pacific 11 0.56 687,675 13,284,234
Africa 1 -- 5,291 50,317
Latin America 1 -- 219 3,581

Location: Country

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