Ownership Summary

Ownership Summary

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 240 3,091.00 105.59 130,749,493
Mutual Fund 381 955.49 40.26 49,816,127
Insider 5 9.56 0.68 838,597

* Insider values reflect direct beneficial ownership.

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 131 554.92 18.40 22,780,983
Sellers 115 -446.32 15.28 -18,916,590
Net 108.59 3.12 3,864,393

Concentration

Value ($MM) % O/S Shares
Total Inst. 3,103.11 106.35 131,692,090
Top 10 Inst. 1,786.96 61.91 76,659,162
Top 20 Inst. 2,421.38 82.80 102,532,800
Top 50 Inst. 2,861.86 97.85 121,167,408

Style

Holders Value ($MM) % Inst Shares Shares
Growth 60 279.62 9.41 11,646,970
Aggressive Growth 7 12.42 0.42 522,133
Core Growth 43 235.16 7.93 9,815,380
Growth 10 32.04 1.06 1,309,457
Income 3 180.23 5.94 7,355,168
Income Value 2 179.88 5.92 7,336,041
Yield 1 0.35 0.02 19,127
Index 28 632.78 20.92 25,901,867
Other 86 1,868.03 64.80 80,243,643
Broker Dealer 18 97.34 3.21 3,973,447
GARP 26 287.48 9.55 11,830,780
Hedge Fund 34 897.80 29.70 36,783,542
Specialty 2 2.11 0.07 86,145
VC Private Equity 5 447.24 17.78 22,021,403
Sector Specific 1 136.04 4.48 5,548,326
Value 28 76.03 2.53 3,133,245
Core Value 22 59.46 1.98 2,455,752
Deep Value 6 16.57 0.55 677,493

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Perceptive Advisors LLC 11,915,127 9.62 -320,684 6/30/19
Avoro Capital Advisors LLC 10,752,585 8.68 221,723 6/30/19
The Vanguard Group, Inc. 8,491,841 6.86 2,688,963 6/30/19
BlackRock Institutional Trust Company, N.A. 8,268,929 6.68 137,288 6/30/19
Quogue Capital L.L.C. 7,067,333 5.71 -- 4/18/19
Franklin Advisers, Inc. 7,013,282 5.66 -1,212,617 6/30/19
T. Rowe Price Associates, Inc. 6,023,903 4.86 2,531,169 6/30/19
Consonance Capital Management LP 5,852,836 4.73 4,712,836 6/30/19
Farallon Capital Management, L.L.C. 5,725,000 4.62 -- 6/30/19
OrbiMed Advisors, LLC 5,548,326 4.48 -- 6/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 3,159,077 2.55 10,984 9/30/19
Franklin Templeton Invest-Biotechnology Discovery 3,016,579 2.44 -- 9/30/19
T. Rowe Price Health Sciences Fund 2,750,716 2.22 161,900 9/30/19
Vanguard Small-Cap Index Fund 2,714,099 2.19 955,702 9/30/19
iShares Russell 2000 ETF 2,584,672 2.09 194,654 9/30/19
T. Rowe Price New Horizons Fund 2,582,186 2.09 170,300 9/30/19
SPDR S&P Biotech ETF 2,358,928 1.91 1,225,378 9/30/19
Franklin Biotechnology Discovery Fund 1,990,500 1.61 -- 8/31/19
Credit Suisse (Lux) Digital Health Equity Fund 1,800,000 1.45 -- 1/31/19
Vanguard Small-Cap Value Index Fund 1,655,666 1.34 570,141 9/30/19

Location: Global Region

Holders % O/S Shares Share Value
North America 190 101.89 126,169,129 2,978,257,867
Europe 40 3.90 4,829,142 111,512,562
Asia / Pacific 13 0.56 688,310 13,282,016
Africa 1 -- 5,291 50,317
Latin America 1 -- 218 5,345

Location: Country

Copyright Thomson Reuters Corporation