Ownership Summary

Ownership Summary

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 230 2,122.59 109.53 135,635,472
Mutual Fund 356 998.01 35.01 43,242,146
Insider 5 9.56 0.68 838,597

* Insider values reflect direct beneficial ownership.

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 125 542.38 17.87 22,134,463
Sellers 112 -447.36 15.30 -18,950,530
Net 95.02 2.57 3,183,933

Concentration

Value ($MM) % O/S Shares
Total Inst. 3,091.36 105.61 130,775,085
Top 10 Inst. 1,786.96 61.91 76,659,162
Top 20 Inst. 2,421.38 82.80 102,532,800
Top 50 Inst. 2,876.75 98.00 121,348,552

Style

Holders Value ($MM) % Inst Shares Shares
Growth 53 212.77 9.72 12,041,920
Aggressive Growth 7 10.01 0.44 540,890
Core Growth 37 174.78 8.18 10,126,840
Growth 9 27.99 1.11 1,374,190
Income 3 86.63 6.92 8,568,379
Income Value 2 86.14 6.90 8,548,658
Yield 1 0.48 0.02 19,721
Index 26 577.51 21.27 26,341,400
Other 87 1,137.62 67.61 83,719,586
Broker Dealer 19 35.75 2.45 3,031,047
GARP 23 142.88 6.79 8,403,418
Hedge Fund 37 654.45 36.21 44,845,198
Specialty 2 0.87 0.07 91,917
VC Private Equity 5 250.89 17.60 21,799,680
Sector Specific 1 52.76 4.48 5,548,326
Value 27 68.69 2.38 2,942,818
Core Value 21 52.81 1.83 2,270,532
Deep Value 6 15.88 0.54 672,286

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Perceptive Advisors LLC 11,915,127 9.62 -320,684 6/30/19
Avoro Capital Advisors LLC 10,752,585 8.68 221,723 6/30/19
The Vanguard Group, Inc. 8,491,841 6.86 2,688,963 6/30/19
BlackRock Institutional Trust Company, N.A. 8,268,929 6.68 137,288 6/30/19
Quogue Capital L.L.C. 7,067,333 5.71 -- 4/18/19
Franklin Advisers, Inc. 7,013,282 5.66 -1,212,617 6/30/19
T. Rowe Price Associates, Inc. 6,023,903 4.86 2,531,169 6/30/19
Consonance Capital Management LP 5,852,836 4.73 4,712,836 6/30/19
Farallon Capital Management, L.L.C. 5,725,000 4.62 -- 6/30/19
OrbiMed Advisors, LLC 5,548,326 4.48 -- 6/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Franklin Templeton Invest-Biotechnology Discovery 3,247,479 2.62 -191,700 6/30/19
Vanguard Total Stock Market Index Fund 3,145,206 2.54 239 6/30/19
T. Rowe Price Health Sciences Fund 2,588,816 2.09 793,000 6/30/19
iShares Russell 2000 ETF 2,489,030 2.01 97,485 7/31/19
T. Rowe Price New Horizons Fund 2,411,886 1.95 1,314,900 6/30/19
Franklin Biotechnology Discovery Fund 1,990,500 1.61 -112,300 6/30/19
Credit Suisse (Lux) Glb Digital Health Equity Fd 1,800,000 1.45 -- 1/31/19
Vanguard Extended Market Index Fund 1,702,054 1.37 -8,610 6/30/19
Fidelity Select Biotechnology Portfolio 1,638,818 1.32 794,930 6/30/19
Franklin Small Cap Growth Fund 1,612,500 1.30 -636,400 6/30/19

Location: Global Region

Holders % O/S Shares Share Value
North America 184 104.69 129,634,725 2,019,524,436
Europe 38 4.97 6,157,271 100,960,431
Asia / Pacific 12 0.63 780,782 14,164,967
Africa 1 -- 5,291 50,317

Location: Country

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