Ownership Summary

Ownership Summary

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 238 2,374.10 104.51 131,698,886
Mutual Fund 400 1,247.41 39.62 49,853,284
Insider 5 12.26 0.66 824,459

* Insider values reflect direct beneficial ownership.

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 115 251.76 10.87 13,714,369
Sellers 130 -350.49 13.78 -17,389,410
Net -98.73 2.91 -3,675,041

Concentration

Value ($MM) % O/S Shares
Total Inst. 2,386.14 105.17 132,526,076
Top 10 Inst. 1,360.98 61.46 77,419,821
Top 20 Inst. 1,774.14 79.45 100,120,866
Top 50 Inst. 2,174.60 96.50 121,612,696

Style

Holders Value ($MM) % Inst Shares Shares
Growth 56 243.59 10.33 13,031,766
Aggressive Growth 7 11.01 0.47 597,010
Core Growth 39 209.84 8.87 11,190,401
Growth 10 22.74 0.99 1,244,355
Income 3 124.96 5.43 6,856,183
Income Value 2 124.45 5.42 6,837,962
Yield 1 0.50 0.01 18,221
Index 25 539.35 23.33 29,430,049
Other 91 1,340.44 60.10 75,699,689
Broker Dealer 18 83.75 3.65 4,601,631
GARP 29 243.60 10.34 13,046,660
Hedge Fund 36 385.78 16.60 20,942,796
Specialty 2 1.60 0.07 87,937
VC Private Equity 5 524.74 25.05 31,472,339
Sector Specific 1 100.98 4.40 5,548,326
Value 26 74.19 3.16 3,956,660
Core Value 20 62.53 2.67 3,347,359
Deep Value 6 11.66 0.48 609,301

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Perceptive Advisors LLC 11,014,702 8.73 -900,425 9/30/19
Avoro Capital Advisors LLC 10,601,039 8.40 -151,546 9/30/19
The Vanguard Group, Inc. 10,528,180 8.34 2,036,339 9/30/19
BlackRock Institutional Trust Company, N.A. 8,339,179 6.61 70,250 9/30/19
Quogue Capital L.L.C. 7,067,333 5.71 -- 4/18/19
Franklin Advisers, Inc. 6,530,176 5.17 -483,106 9/30/19
T. Rowe Price Associates, Inc. 6,505,083 5.15 481,180 9/30/19
Farallon Capital Management, L.L.C. 6,025,000 4.77 300,000 9/30/19
OrbiMed Advisors, LLC 5,548,326 4.40 -- 9/30/19
Great Point Partners, LLC 5,260,803 4.17 -- 9/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 3,223,469 2.55 93,920 12/31/19
Vanguard Small-Cap Index Fund 2,846,462 2.26 57,261 12/31/19
iShares Russell 2000 ETF 2,686,592 2.13 88,111 12/31/19
T. Rowe Price Health Sciences Fund 2,559,921 2.03 -190,795 12/31/19
T. Rowe Price New Horizons Fund 2,524,022 2.00 -58,164 12/31/19
Franklin Templeton Invest-Biotechnology Discovery 2,303,579 1.83 -555,800 12/31/19
SPDR S&P Biotech ETF 1,904,679 1.51 -485,194 12/31/19
Credit Suisse (Lux) Digital Health Equity Fund 1,800,000 1.43 -- 1/31/19
Vanguard Small-Cap Value Index Fund 1,749,387 1.39 32,266 12/31/19
Franklin Biotechnology Discovery Fund 1,663,700 1.32 -232,100 12/31/19

Location: Global Region

Holders % O/S Shares Share Value
North America 187 101.11 127,400,069 2,280,129,590
Europe 41 3.82 4,815,784 102,286,358
Asia / Pacific 12 0.24 300,372 3,814,226
Africa 1 0.01 6,861 124,870
Latin America 1 -- 259 4,714

Location: Country

Copyright Thomson Reuters Corporation