Ownership Summary

Ownership Summary

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 239 2,359.82 104.78 132,000,275
Mutual Fund 392 1,029.53 40.33 50,487,594
Insider 5 12.81 0.66 826,021

* Insider values reflect direct beneficial ownership.

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 117 248.50 10.79 13,622,603
Sellers 128 -350.42 13.86 -17,486,196
Net -101.92 3.06 -3,863,593

Concentration

Value ($MM) % O/S Shares
Total Inst. 2,372.63 105.44 132,826,296
Top 10 Inst. 1,360.98 61.46 77,419,821
Top 20 Inst. 1,774.06 79.44 100,116,369
Top 50 Inst. 2,166.82 96.64 121,768,638

Style

Holders Value ($MM) % Inst Shares Shares
Growth 57 245.57 10.61 13,370,701
Aggressive Growth 7 10.97 0.47 597,518
Core Growth 39 206.18 8.96 11,293,418
Growth 11 28.42 1.18 1,479,765
Income 3 124.87 5.43 6,856,183
Income Value 2 124.45 5.42 6,837,962
Yield 1 0.42 0.01 18,221
Index 25 536.50 23.30 29,399,592
Other 91 1,331.12 60.07 75,651,677
Broker Dealer 18 83.67 3.64 4,597,134
GARP 29 236.32 10.20 12,858,983
Hedge Fund 36 383.81 16.72 21,086,958
Specialty 2 1.60 0.07 87,937
VC Private Equity 5 524.74 25.05 31,472,339
Sector Specific 1 100.98 4.40 5,548,326
Value 27 73.40 3.21 4,023,961
Core Value 21 61.07 2.67 3,346,055
Deep Value 6 12.34 0.54 677,906

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Perceptive Advisors LLC 11,014,702 8.73 -900,425 9/30/19
Avoro Capital Advisors LLC 10,601,039 8.40 -151,546 9/30/19
The Vanguard Group, Inc. 10,528,180 8.34 2,036,339 9/30/19
BlackRock Institutional Trust Company, N.A. 8,339,179 6.61 70,250 9/30/19
Quogue Capital L.L.C. 7,067,333 5.71 -- 4/18/19
Franklin Advisers, Inc. 6,530,176 5.17 -483,106 9/30/19
T. Rowe Price Associates, Inc. 6,505,083 5.15 481,180 9/30/19
Farallon Capital Management, L.L.C. 6,025,000 4.77 300,000 9/30/19
OrbiMed Advisors, LLC 5,548,326 4.40 -- 9/30/19
Great Point Partners, LLC 5,260,803 4.17 -- 9/30/19

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Total Stock Market Index Fund 3,150,782 2.50 -8,295 10/31/19
Franklin Templeton Invest-Biotechnology Discovery 3,016,579 2.39 -- 10/31/19
Vanguard Small-Cap Index Fund 2,784,845 2.21 70,746 10/31/19
T. Rowe Price Health Sciences Fund 2,750,716 2.18 161,900 9/30/19
T. Rowe Price New Horizons Fund 2,582,186 2.05 170,300 9/30/19
iShares Russell 2000 ETF 2,557,349 2.03 -27,323 10/31/19
SPDR S&P Biotech ETF 2,389,873 1.89 123,375 11/30/19
Franklin Biotechnology Discovery Fund 1,990,500 1.58 -- 10/31/19
Credit Suisse (Lux) Digital Health Equity Fund 1,800,000 1.43 -- 1/31/19
Vanguard Small-Cap Value Index Fund 1,712,207 1.36 56,541 10/31/19

Location: Global Region

Holders % O/S Shares Share Value
North America 189 101.52 127,892,110 2,280,845,783
Europe 40 3.69 4,644,663 88,398,619
Asia / Pacific 12 0.23 282,341 3,209,184
Africa 1 0.01 6,923 169,752
Latin America 1 -- 259 6,369

Location: Country

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